Assay Detail
Functional
CHEMBL4231092
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-parasitic activity against bloodstream trypomastigote stage of wild-type Trypanosoma brucei brucei Lister 427 after 48 hrs in presence of 5 mM glycerol by resazurin-based assay
30
Total Activities
30
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 6.02 | 9.41 |
| MIC | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4249714 | — | — | 1 | 9.41 |
| CHEMBL4245918 | — | — | 1 | 8.85 |
| CHEMBL4250711 | — | — | 1 | 8.49 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.40 |
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 7.20 |
| CHEMBL4247258 | — | — | 1 | 7.17 |
| CHEMBL4244022 | — | — | 1 | 7.15 |
| CHEMBL4237349 | — | — | 1 | 6.84 |
| CHEMBL4237238 | — | — | 1 | 5.91 |
| CHEMBL4240979 | — | — | 1 | 5.75 |
| CHEMBL4239171 | — | — | 1 | 5.29 |
| CHEMBL4090897 | — | — | 1 | 5.21 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | — | 1 | 5.16 |
| CHEMBL4237659 | — | — | 1 | 5.14 |
| CHEMBL4248268 | — | — | 1 | 5.12 |
| CHEMBL4247810 | — | — | 1 | 5.11 |
| CHEMBL4250174 | — | — | 1 | 5.11 |
| CHEMBL4237726 | — | — | 1 | 4.97 |
| CHEMBL4069905 | — | — | 1 | 4.96 |
| CHEMBL4251018 | — | — | 1 | 4.92 |
| CHEMBL4244828 | — | — | 1 | 4.91 |
| CHEMBL4241528 | — | — | 1 | 4.91 |
| CHEMBL4241091 | — | — | 1 | 4.87 |
| CHEMBL4245303 | — | — | 1 | 4.80 |
| CHEMBL4068891 | — | — | 1 | 4.76 |
| CHEMBL4249095 | — | — | 1 | - |
| CHEMBL4243481 | — | — | 1 | - |
| CHEMBL328910 | 2,4-DIHYDROXYBENZOIC ACID | — | 1 | - |
| CHEMBL133046 | ASCOFURANONE | — | 1 | - |
| CHEMBL4241625 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4249714 | — | EC50 | = | 0.39 | nM | 9.41 |
| CHEMBL4245918 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4250711 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL55 | PENTAMIDINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL35241 | DIMINAZENE | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4247258 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4244022 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4237349 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4237238 | — | EC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL4240979 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4239171 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4090897 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4237659 | — | EC50 | = | 7190.0 | nM | 5.14 |
| CHEMBL4248268 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4247810 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4250174 | — | EC50 | = | 7710.0 | nM | 5.11 |
| CHEMBL4237726 | — | EC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL4069905 | — | EC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL4251018 | — | EC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL4244828 | — | EC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4241528 | — | EC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4241091 | — | EC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL4245303 | — | EC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4068891 | — | EC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL4249095 | — | EC50 | = | 400000.0 | nM | - |
| CHEMBL4243481 | — | EC50 | = | 400000.0 | nM | - |
| CHEMBL328910 | 2,4-DIHYDROXYBENZOIC ACID | EC50 | - | — | - | |
| CHEMBL133046 | ASCOFURANONE | MIC | = | 30000.0 | nM | - |
| CHEMBL4241625 | — | EC50 | = | 400000.0 | nM | - |