Assay Detail
Functional
CHEMBL3998913
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Trypanocidal activity against bloodstream trypomastigote stage of wild-type Trypanosoma brucei brucei Lister 427 assessed as inhibition of respiration in presence of glycerol
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.39 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4098620 | — | — | 1 | 9.10 |
| CHEMBL4099534 | — | — | 1 | 8.92 |
| CHEMBL4072631 | — | — | 1 | 8.70 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.40 |
| CHEMBL4061239 | — | — | 1 | 8.30 |
| CHEMBL4080586 | — | — | 1 | 8.30 |
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 7.20 |
| CHEMBL4086675 | — | — | 1 | 7.11 |
| CHEMBL4083110 | — | — | 1 | 7.08 |
| CHEMBL4104576 | — | — | 1 | 7.05 |
| CHEMBL4078575 | — | — | 1 | 6.80 |
| CHEMBL4096176 | — | — | 1 | 6.64 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | — | 1 | 5.16 |
| CHEMBL328910 | 2,4-DIHYDROXYBENZOIC ACID | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4098620 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4099534 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4072631 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL55 | PENTAMIDINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4061239 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4080586 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL35241 | DIMINAZENE | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4086675 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4083110 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4104576 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4078575 | — | EC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4096176 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL328910 | 2,4-DIHYDROXYBENZOIC ACID | EC50 | = | 19000.0 | nM | 4.72 |