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Assay Detail

CHEMBL1173876

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma brucei brucei
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei brucei (CHEMBL612851)
Type ORGANISM
Organism Trypanosoma brucei brucei

Publication

7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata.
Davis RA, Demirkiran O, Sykes ML, Avery VM, Suraweera L, Fechner GA, Quinn RJ.
Bioorg Med Chem Lett (2010) 20 : 4057 -4059
PubMed 20558060 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 6 6.80 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL55 PENTAMIDINE 4.0 1 8.15
CHEMBL35241 DIMINAZENE 2.0 1 7.60
CHEMBL469912 PUROMYCIN 2.0 1 7.43
CHEMBL1170809 1 5.55
CHEMBL452184 OBOLACTONE 1 5.28
CHEMBL1170808 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL55 PENTAMIDINE IC50 = 7.0 nM 8.15
CHEMBL35241 DIMINAZENE IC50 = 25.0 nM 7.60
CHEMBL469912 PUROMYCIN IC50 = 37.0 nM 7.43
CHEMBL1170809 IC50 = 2800.0 nM 5.55
CHEMBL452184 OBOLACTONE IC50 = 5300.0 nM 5.28
CHEMBL1170808 IC50 > 167000.0 nM -