Assay Detail
Functional
CHEMBL1017257
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Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 in human erythrocytes by DAPI stain
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 7.14 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.40 |
| CHEMBL462360 | — | — | 1 | 8.30 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.15 |
| CHEMBL99254 | — | — | 1 | 7.24 |
| CHEMBL518668 | — | — | 1 | 7.21 |
| CHEMBL446641 | — | — | 1 | 7.16 |
| CHEMBL461156 | — | — | 1 | 7.16 |
| CHEMBL513592 | — | — | 1 | 7.09 |
| CHEMBL513579 | — | — | 1 | 7.07 |
| CHEMBL512859 | — | — | 1 | 7.04 |
| CHEMBL472391 | — | — | 1 | 7.00 |
| CHEMBL472397 | — | — | 1 | 6.96 |
| CHEMBL471351 | — | — | 1 | 6.85 |
| CHEMBL471352 | — | — | 1 | 6.62 |
| CHEMBL513456 | — | — | 1 | 6.48 |
| CHEMBL461155 | — | — | 1 | 6.31 |
| CHEMBL470315 | — | — | 1 | 6.26 |
| CHEMBL472398 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL462360 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL99254 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL518668 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL446641 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL461156 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL513592 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL513579 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL512859 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL472391 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL472397 | — | EC50 | = | 109.0 | nM | 6.96 |
| CHEMBL471351 | — | EC50 | = | 141.0 | nM | 6.85 |
| CHEMBL471352 | — | EC50 | = | 241.0 | nM | 6.62 |
| CHEMBL513456 | — | EC50 | = | 332.0 | nM | 6.48 |
| CHEMBL461155 | — | EC50 | = | 485.0 | nM | 6.31 |
| CHEMBL470315 | — | EC50 | = | 545.0 | nM | 6.26 |
| CHEMBL472398 | — | EC50 | > | 1000.0 | nM | - |