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Compound Detail

CHEMBL512859

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CC1CCCC2(C1)CC(C)(CCOCc1ccccc1)OO2

Basic Information

ChEMBL ID CHEMBL512859
Phase Preclinical
Structure Type MOL
InChI Key IDCKVARGJWZJOA-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

304.4
MW (Da)
4.65
ALogP
3
HBA
0
HBD
27.7
PSA (Ų)
0.59
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H28O3
MW 304.43
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness 0.97

Activity Summary

EC50 2 meas. best 7.04

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Plasmodium falciparum
CHEMBL364
EC50 7.04 6.93 92.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18993067 10.1016/j.bmcl.2008.10.083 Plasmodium falciparum 2
18993067 10.1016/j.bmcl.2008.10.083 Heme 1

Data from ChEMBL 36 via Core Engine