Assay Detail
Functional
CHEMBL1017258
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Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-resistant Plasmodium falciparum Dd2 in human erythrocytes by DAPI stain
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 7.12 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.40 |
| CHEMBL462360 | — | — | 1 | 8.22 |
| CHEMBL513592 | — | — | 1 | 7.24 |
| CHEMBL470315 | — | — | 1 | 7.23 |
| CHEMBL446641 | — | — | 1 | 7.21 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.18 |
| CHEMBL513579 | — | — | 1 | 7.13 |
| CHEMBL472391 | — | — | 1 | 7.11 |
| CHEMBL461156 | — | — | 1 | 7.11 |
| CHEMBL461155 | — | — | 1 | 7.00 |
| CHEMBL518668 | — | — | 1 | 6.97 |
| CHEMBL472397 | — | — | 1 | 6.94 |
| CHEMBL471351 | — | — | 1 | 6.84 |
| CHEMBL471352 | — | — | 1 | 6.83 |
| CHEMBL512859 | — | — | 1 | 6.82 |
| CHEMBL99254 | — | — | 1 | 6.81 |
| CHEMBL513456 | — | — | 1 | 6.05 |
| CHEMBL472398 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL462360 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL513592 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL470315 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL446641 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL513579 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL472391 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL461156 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL461155 | — | EC50 | = | 99.0 | nM | 7.00 |
| CHEMBL518668 | — | EC50 | = | 108.0 | nM | 6.97 |
| CHEMBL472397 | — | EC50 | = | 114.0 | nM | 6.94 |
| CHEMBL471351 | — | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL471352 | — | EC50 | = | 149.0 | nM | 6.83 |
| CHEMBL512859 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL99254 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL513456 | — | EC50 | = | 897.0 | nM | 6.05 |
| CHEMBL472398 | — | EC50 | > | 1000.0 | nM | - |