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Assay Detail

CHEMBL1017706

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]diazepam from benzodiazepine receptor in rat brain
ChEMBL ↗
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Brain
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

3D and quantum QSAR of non-benzodiazepine compounds.
Pasha FA, Muddassar M, Cho SJ, Ahmad K, Beg Y.
Eur J Med Chem (2008) 43 : 2361 -2372
PubMed 18346822 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 54 6.27 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL453066 BETA-CCM — 1 8.30
CHEMBL11709 — — 1 8.30
CHEMBL307783 — — 1 8.00
CHEMBL56243 — — 1 7.96
CHEMBL52750 — — 1 7.96
CHEMBL69719 — — 1 7.64
CHEMBL299250 — — 1 7.62
CHEMBL61684 — — 1 7.60
CHEMBL293038 — — 1 7.47
CHEMBL298561 — — 1 7.35
CHEMBL507888 — — 1 7.03
CHEMBL458669 — — 1 7.02
CHEMBL66902 — — 1 7.01
CHEMBL60919 — — 1 6.96
CHEMBL292555 — — 1 6.96
CHEMBL54228 — — 1 6.91
CHEMBL53229 — — 1 6.90
CHEMBL292062 — — 1 6.89
CHEMBL293203 — — 1 6.72
CHEMBL69488 — — 1 6.64
CHEMBL504584 — — 1 6.45
CHEMBL292295 — — 1 6.44
CHEMBL7474 — — 1 6.36
CHEMBL456710 — — 1 6.33
CHEMBL67421 — — 1 6.29
CHEMBL456711 — — 1 6.27
CHEMBL60774 — — 1 6.22
CHEMBL67951 — — 1 6.12
CHEMBL60940 — — 1 6.08
CHEMBL7344 — — 1 6.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL453066 BETA-CCM IC50 = 5.012 nM 8.30
CHEMBL11709 — IC50 = 5.012 nM 8.30
CHEMBL307783 — IC50 = 10.0 nM 8.00
CHEMBL56243 — IC50 = 10.96 nM 7.96
CHEMBL52750 — IC50 = 10.96 nM 7.96
CHEMBL69719 — IC50 = 22.91 nM 7.64
CHEMBL299250 — IC50 = 23.99 nM 7.62
CHEMBL61684 — IC50 = 25.12 nM 7.60
CHEMBL293038 — IC50 = 33.88 nM 7.47
CHEMBL298561 — IC50 = 44.67 nM 7.35
CHEMBL507888 — IC50 = 93.33 nM 7.03
CHEMBL458669 — IC50 = 95.5 nM 7.02
CHEMBL66902 — IC50 = 97.72 nM 7.01
CHEMBL292555 — IC50 = 109.65 nM 6.96
CHEMBL60919 — IC50 = 109.65 nM 6.96
CHEMBL54228 — IC50 = 123.03 nM 6.91
CHEMBL53229 — IC50 = 125.89 nM 6.90
CHEMBL292062 — IC50 = 128.82 nM 6.89
CHEMBL293203 — IC50 = 190.55 nM 6.72
CHEMBL69488 — IC50 = 229.09 nM 6.64
CHEMBL504584 — IC50 = 354.81 nM 6.45
CHEMBL292295 — IC50 = 363.08 nM 6.44
CHEMBL7474 — IC50 = 436.52 nM 6.36
CHEMBL456710 — IC50 = 467.74 nM 6.33
CHEMBL67421 — IC50 = 512.86 nM 6.29
CHEMBL456711 — IC50 = 537.03 nM 6.27
CHEMBL60774 — IC50 = 602.56 nM 6.22
CHEMBL67951 — IC50 = 758.58 nM 6.12
CHEMBL60940 — IC50 = 831.76 nM 6.08
CHEMBL7344 — IC50 = 891.25 nM 6.05
CHEMBL293769 — IC50 = 1000.0 nM 6.00
CHEMBL454254 — IC50 = 1000.0 nM 6.00
CHEMBL7293 — IC50 = 1202.26 nM 5.92
CHEMBL291875 — IC50 = 1513.56 nM 5.82
CHEMBL7553 — IC50 = 1584.89 nM 5.80
CHEMBL275224 NORHARMANE IC50 = 1621.81 nM 5.79
CHEMBL292401 — IC50 = 1819.7 nM 5.74
CHEMBL60971 — IC50 = 3019.95 nM 5.52
CHEMBL7881 — IC50 = 5011.87 nM 5.30
CHEMBL293221 — IC50 = 5248.07 nM 5.28
CHEMBL303518 — IC50 = 5370.32 nM 5.27
CHEMBL6917 — IC50 = 5370.32 nM 5.27
CHEMBL302878 — IC50 = 5754.4 nM 5.24
CHEMBL439754 — IC50 = 7244.36 nM 5.14
CHEMBL7141 — IC50 = 7244.36 nM 5.14
CHEMBL12063 — IC50 = 7585.78 nM 5.12
CHEMBL62399 — IC50 = 7943.28 nM 5.10
CHEMBL60841 — IC50 = 8511.38 nM 5.07
CHEMBL12014 HARMAN IC50 = 12302.69 nM 4.91
CHEMBL6889 — IC50 = 12882.5 nM 4.89