Compound Detail
CHEMBL275224
NORHARMANE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL275224 |
| Name | NORHARMANE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AIFRHYZBTHREPW-UHFFFAOYSA-N |
15
Targets
29
Activities
3
Assay Types
1
PK Parameters
20
Publications
0
Known Names
Molecular Properties
168.2
MW (Da)
2.72
ALogP
1
HBA
1
HBD
28.7
PSA (Ų)
0.55
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 17 meas. best 5.92
Ki 9 meas. best 6.92
EC50 3 meas. best 5.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Indoleamine 2,3-dioxygenase 1 CHEMBL4685 | Ki | 6.92 | 6.92 | 120.0 | 1 |
| Amine oxidase [flavin-containing] A CHEMBL1951 | Ki | 6.58 | 6.58 | 260.0 | 1 |
| Amine oxidase [flavin-containing] B CHEMBL2039 | Ki | 5.95 | 5.935 | 1120.0 | 2 |
| Tryptophan 2,3-dioxygenase CHEMBL2140 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
| GABA-A receptor; anion channel CHEMBL2093872 | IC50 | 5.8 | 5.795 | 1600.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 5.79 | 5.79 | 1620.0 | 4 |
| GABA-A receptor; anion channel CHEMBL1907607 | IC50 | 5.79 | 5.79 | 1620.0 | 4 |
| GABA-A receptor; anion channel CHEMBL1907607 | Ki | 5.79 | 5.79 | 1620.0 | 1 |
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | Ki | 5.2 | 5.2 | 6309.6 | 1 |
| Inhibitor of nuclear factor kappa-B kinase subunit beta CHEMBL1991 | Ki | 5.1 | 5.1 | 7943.3 | 1 |
| Chitinase CHEMBL1795119 | IC50 | 5.07 | 5.07 | 8460.0 | 1 |
| Bovine viral diarrhea virus 1 CHEMBL612571 | EC50 | 5.06 | 5.06 | 8800.0 | 2 |
| Inhibitor of nuclear factor kappa-B kinase subunit alpha CHEMBL3476 | IC50 | 4.82 | 4.82 | 15000.0 | 1 |
| Aurora kinase A CHEMBL4722 | Ki | 4.8 | 4.8 | 15848.9 | 1 |
| DNA topoisomerase 1 CHEMBL1781 | IC50 | 4.51 | 4.51 | 31000.0 | 1 |
| Human immunodeficiency virus 1 CHEMBL378 | EC50 | 4.36 | 4.36 | 44100.0 | 1 |
| Indoleamine 2,3-dioxygenase 1 CHEMBL4685 | IC50 | 4.05 | 4.05 | 90000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 89.0 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine