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Assay Detail

CHEMBL1963726

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PIM1
ChEMBL ↗
1160
Total Activities
1141
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1160 5.83 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1974870 — — 1 8.30
CHEMBL1965836 — — 1 8.30
CHEMBL523823 — — 1 8.20
CHEMBL1991063 — — 1 8.20
CHEMBL1970903 — — 1 8.10
CHEMBL1994361 — — 1 8.00
CHEMBL2000271 — — 1 8.00
CHEMBL360847 — — 1 7.70
CHEMBL1870106 — — 1 7.70
CHEMBL326282 — — 1 7.60
CHEMBL1969537 — — 1 7.60
CHEMBL1974250 — — 1 7.60
CHEMBL379975 — — 1 7.50
CHEMBL1966808 — — 1 7.50
CHEMBL2003637 — — 1 7.50
CHEMBL1996980 — — 1 7.50
CHEMBL1987679 — — 1 7.40
CHEMBL1973098 — — 1 7.40
CHEMBL468280 — — 1 7.40
CHEMBL1967302 — — 1 7.40
CHEMBL2004443 — — 1 7.30
CHEMBL2000685 — — 1 7.30
CHEMBL1990583 — — 1 7.20
CHEMBL1983589 — — 1 7.20
CHEMBL1972840 — — 1 7.20
CHEMBL2001920 — — 1 7.20
CHEMBL396523 — — 1 7.20
CHEMBL226403 — — 1 7.10
CHEMBL1966524 — — 1 7.10
CHEMBL1986265 — — 1 7.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1965836 — Ki = 5.012 nM 8.30
CHEMBL1974870 — Ki = 5.012 nM 8.30
CHEMBL1991063 — Ki = 6.31 nM 8.20
CHEMBL523823 — Ki = 6.31 nM 8.20
CHEMBL1970903 — Ki = 7.943 nM 8.10
CHEMBL1994361 — Ki = 10.0 nM 8.00
CHEMBL2000271 — Ki = 10.0 nM 8.00
CHEMBL1870106 — Ki = 19.95 nM 7.70
CHEMBL360847 — Ki = 19.95 nM 7.70
CHEMBL1974250 — Ki = 25.12 nM 7.60
CHEMBL326282 — Ki = 25.12 nM 7.60
CHEMBL1969537 — Ki = 25.12 nM 7.60
CHEMBL2003637 — Ki = 31.62 nM 7.50
CHEMBL379975 — Ki = 31.62 nM 7.50
CHEMBL1966808 — Ki = 31.62 nM 7.50
CHEMBL1996980 — Ki = 31.62 nM 7.50
CHEMBL1987679 — Ki = 39.81 nM 7.40
CHEMBL1973098 — Ki = 39.81 nM 7.40
CHEMBL468280 — Ki = 39.81 nM 7.40
CHEMBL1967302 — Ki = 39.81 nM 7.40
CHEMBL2000685 — Ki = 50.12 nM 7.30
CHEMBL2004443 — Ki = 50.12 nM 7.30
CHEMBL1990583 — Ki = 63.1 nM 7.20
CHEMBL2001920 — Ki = 63.1 nM 7.20
CHEMBL396523 — Ki = 63.1 nM 7.20
CHEMBL1983589 — Ki = 63.1 nM 7.20
CHEMBL1972840 — Ki = 63.1 nM 7.20
CHEMBL1988581 — Ki = 79.43 nM 7.10
CHEMBL226403 — Ki = 79.43 nM 7.10
CHEMBL1988141 — Ki = 79.43 nM 7.10
CHEMBL1966524 — Ki = 79.43 nM 7.10
CHEMBL1986265 — Ki = 79.43 nM 7.10
CHEMBL2002346 — Ki = 100.0 nM 7.00
CHEMBL1996510 — Ki = 100.0 nM 7.00
CHEMBL2007592 — Ki = 100.0 nM 7.00
CHEMBL2002726 — Ki = 100.0 nM 7.00
CHEMBL1985074 — Ki = 100.0 nM 7.00
CHEMBL302449 GO-6976 Ki = 100.0 nM 7.00
CHEMBL1991640 — Ki = 125.89 nM 6.90
CHEMBL1967544 — Ki = 125.89 nM 6.90
CHEMBL1980178 — Ki = 125.89 nM 6.90
CHEMBL451964 — Ki = 125.89 nM 6.90
CHEMBL1973720 — Ki = 125.89 nM 6.90
CHEMBL1998432 — Ki = 125.89 nM 6.90
CHEMBL2000354 — Ki = 125.89 nM 6.90
CHEMBL1973720 — Ki = 125.89 nM 6.90
CHEMBL2004156 — Ki = 125.89 nM 6.90
CHEMBL1999774 — Ki = 125.89 nM 6.90
CHEMBL583144 — Ki = 125.89 nM 6.90
CHEMBL1995932 — Ki = 125.89 nM 6.90