Compound Detail
CHEMBL451964
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Basic Information
| ChEMBL ID | CHEMBL451964 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IRFDEDLBWHFGGS-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
319.3
MW (Da)
3.38
ALogP
5
HBA
1
HBD
55.1
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | Ki | 6.9 | 6.7 | 125.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | Ki | = | 125.89 | nM | 6.9 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Serine/threonine-protein kinase pim-1 | Ki | = | 320.0 | nM | 6.5 | Inhibition of Pim1 assessed as [32P] incorporation preincubated for 15 mins befo... | 19414255 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19414255 | 10.1016/j.bmcl.2009.04.061 | Serine/threonine-protein kinase pim-1 | 1 |
Data from ChEMBL 36 via Core Engine