GABA-A receptor; anion channel · PROTEIN COMPLEX GROUP · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt O09028. Use UniProt O09028 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O09028 as the stable identity anchor, then attach disease evidence before program review.
Gamma-aminobutyric acid receptor subunit pi
Review this target as GABA-A receptor; anion channel, mapped to UniProt O09028. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit pi. Sequence length is 440 aa.
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This review treats GABA-A receptor; anion channel as ChEMBL target CHEMBL1907607, mapped to UniProt O09028. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | GABA-A receptor; anion channel |
| Target Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
| UniProt | O09028 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-aminobutyric acid receptor subunit pi |
| UniProt Accession | O09028 |
| Component Type | Protein |
| Sequence Length | 440 aa |
Gamma-aminobutyric acid receptor subunit pi
Review this target as GABA-A receptor; anion channel, mapped to UniProt O09028. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit pi. Sequence length is 440 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL380906 | 10.32 | Ki | 0.048 | Preclinical |
| CHEMBL3144615 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL3144841 | 10.05 | Ki | 0.09 | Preclinical |
| CHEMBL54338 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL80436 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL3144739 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL413744 | 9.96 | IC50 | 0.11 | Preclinical |
| CHEMBL3144609 | 9.92 | Ki | 0.12 | Preclinical |
| CHEMBL19732 | 9.89 | Ki | 0.13 | Preclinical |
| CHEMBL19732 | 9.89 | IC50 | 0.13 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 149 | 316 | 7.1 |
| cell membrane format | 126 | 781 | 7.0 |
| assay format | 118 | 568 | 6.7 |
| tissue-based format | 106 | 592 | 6.9 |
| subcellular format | 6 | 36 | 6.1 |
| organism-based format | 5 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 17 | 67 | 7.5 |
| organism-based format | 9 | 0 | — |
| cell-based format | 6 | 2 | 4.8 |
| tissue-based format | 2 | 0 | — |
| cell membrane format | 1 | 2 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 3 | 1 | 5.5 |