Compound Detail
CHEMBL4105630
ZURANOLONE 💊 Approved Drug
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💊 Approved Drug
C[C@@]1(O)CC[C@H]2[C@H](CC[C@@H]3[C@@H]2CC[C@]2(C)[C@@H](C(=O)Cn4cc(C#N)cn4)CC[C@@H]32)C1
Basic Information
| ChEMBL ID | CHEMBL4105630 |
| Name | ZURANOLONE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | HARRKNSQXBRBGZ-GVKWWOCJSA-N |
| Therapeutic | ✓ Yes |
5
Targets
8
Activities
2
Assay Types
26
PK Parameters
20
Publications
5
Known Names
7
Indications
1
Mechanisms
Molecular Properties
409.6
MW (Da)
4.34
ALogP
5
HBA
1
HBD
78.9
PSA (Ų)
0.81
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2023 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel | ✓ | ✓ |
Indications
Depression, Postpartum Depressive Disorder Depressive Disorder Depressive Disorder, Major Essential Tremor Parkinson Disease Mood Disorders
ATC Classification
N06AX31
zuranolone
Level 1: NERVOUS SYSTEM
Level 2: PSYCHOANALEPTICS
Drug Warnings
Black Box Warning
General Warning
Activity Summary
EC50 6 meas. best 6.87
IC50 2 meas. best 8.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; anion channel CHEMBL1907607 | IC50 | 8.15 | 8.15 | 7.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 8.15 | 8.15 | 7.0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4/beta3/delta CHEMBL3430899 | EC50 | 6.87 | 6.695 | 135.0 | 2 |
| GABA-A receptor; alpha-1/beta-2/gamma-2 CHEMBL2095172 | EC50 | 6.82 | 6.56 | 152.0 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4/beta-2/delta CHEMBL4296046 | EC50 | 6.79 | 6.79 | 163.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 2131.81 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 4923.03 | ng.hr.mL-1 | Rattus norvegicus |
| CL | 101.67 | mL.min-1.kg-1 | Mus musculus |
| CL | 16.67 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 10.0 | mL.min-1.kg-1 | Canis lupus familiaris |
| CL | 15.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 3.333 | mL.min-1.kg-1 | Homo sapiens |
| CL | 36.67 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 70.0 | mL.min-1.kg-1 | Mus musculus |
| CL | 23.33 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 25.0 | mL.min-1.kg-1 | Mus musculus |
| CL | 10.0 | mL.min-1.kg-1 | Canis lupus familiaris |
| CL | 1.667 | mL.min-1.kg-1 | Canis lupus familiaris |
| CL | 10.0 | % | Canis lupus familiaris |
| CL | 51.8 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 10.6 | mL.min-1.kg-1 | Homo sapiens |
| Cmax | 2290.0 | nM | Rattus norvegicus |
| F | 32.0 | % | Rattus norvegicus |
| F | 62.0 | % | Mus musculus |
| F | 68.0 | % | Canis lupus familiaris |
| F | 57.7 | % | Rattus norvegicus |
| T1/2 | 2.45 | hr | Rattus norvegicus |
| T1/2 | 3.8 | hr | Rattus norvegicus |
| Tmax | 1.17 | hr | Rattus norvegicus |
| Vd | 4.66 | L.kg-1 | Rattus norvegicus |
| Vd | 10.54 | L.kg-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine