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CHEMBL4296046 Target Snapshot

Gamma-aminobutyric acid receptor subunit alpha-4/beta-2/delta · PROTEIN COMPLEX · Homo sapiens

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1Compounds
1Assays
1Approved Drugs
1.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P47870. Use UniProt P47870 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P47870 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Protein anchor
Gamma-aminobutyric acid receptor subunit beta-2

Gamma-aminobutyric acid receptor subunit beta-2

Review this target as Gamma-aminobutyric acid receptor subunit alpha-4/beta-2/delta, mapped to UniProt P47870. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit beta-2. Sequence length is 512 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt P47870 Protein 512 aa
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Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Gamma-aminobutyric acid receptor subunit alpha-4/beta-2/delta as ChEMBL target CHEMBL4296046, mapped to UniProt P47870. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Gamma-aminobutyric acid receptor subunit alpha-4/beta-2/delta
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4296046
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P47870
Gamma-aminobutyric acid receptor subunit beta-2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

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UniProt Target Context
UniProt accession via ChEMBL component mapping

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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Preferred NameGamma-aminobutyric acid receptor subunit alpha-4/beta-2/delta
Target TypePROTEIN COMPLEX
OrganismHomo sapiens
UniProtP47870
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGamma-aminobutyric acid receptor subunit beta-2
UniProt AccessionP47870
Component TypeProtein
Sequence Length512 aa

Gamma-aminobutyric acid receptor subunit beta-2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Gamma-aminobutyric acid receptor subunit alpha-4/beta-2/delta, mapped to UniProt P47870. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit beta-2. Sequence length is 512 aa.

Mapped IDP47870
Review nameGamma-aminobutyric acid receptor subunit alpha-4/beta-2/delta
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4105630 6.79 EC50 163.0 Approved
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ZURANOLONE
CHEMBL4105630
Approved 2023
Properties Compare Identifier
Assay Landscape

Assay Landscape

1
Total Assays
1
Tested Compounds
1
Assay Types
Binding — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
protein complex format 1 1 6.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine