GABA-A receptor; alpha-1/beta-2/gamma-2 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P14867. Use UniProt P14867 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P14867 as the stable identity anchor, then attach disease evidence before program review.
Gamma-aminobutyric acid receptor subunit alpha-1
Review this target as GABA-A receptor; alpha-1/beta-2/gamma-2, mapped to UniProt P14867. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit alpha-1. Sequence length is 456 aa.
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This review treats GABA-A receptor; alpha-1/beta-2/gamma-2 as ChEMBL target CHEMBL2095172, mapped to UniProt P14867. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether GABA-A receptor; alpha-1/beta-2/gamma-2 is the right protein anchor across sources, using UniProt P14867 as the stable mapping.
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| Preferred Name | GABA-A receptor; alpha-1/beta-2/gamma-2 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P14867 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-aminobutyric acid receptor subunit alpha-1 |
| UniProt Accession | P14867 |
| Component Type | Protein |
| Sequence Length | 456 aa |
Gamma-aminobutyric acid receptor subunit alpha-1
Review this target as GABA-A receptor; alpha-1/beta-2/gamma-2, mapped to UniProt P14867. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit alpha-1. Sequence length is 456 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1709464 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL469477 | 9.92 | Ki | 0.12 | Preclinical |
| CHEMBL487686 | 9.92 | Ki | 0.12 | Preclinical |
| CHEMBL488283 | 9.92 | Ki | 0.12 | Preclinical |
| CHEMBL487687 | 9.85 | Ki | 0.14 | Preclinical |
| CHEMBL50763 | 9.77 | Ki | 0.17 | Preclinical |
| CHEMBL48403 | 9.66 | Ki | 0.22 | Preclinical |
| CHEMBL3274851 | 9.59 | Ki | 0.26 | Preclinical |
| CHEMBL381059 | 9.57 | Ki | 0.27 | Preclinical |
| CHEMBL49888 | 9.52 | Ki | 0.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 137 | 183 | 6.2 |
| protein complex format | 27 | 43 | 5.8 |
| assay format | 7 | 13 | 6.4 |
| cell membrane format | 2 | 25 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 27 | 33 | 6.4 |
| assay format | 17 | 6 | 5.0 |