Evidence Snapshot

GABA-A receptor; alpha-1/beta-2/gamma-2

CHEMBL2095172 PROTEIN COMPLEX Homo sapiens

Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:45:14Z

Source · ChEMBL 36 via Core Engine Freshness · Sep 14, 2026, 5:45 AM KST As of · Sep 13, 2026

ChEMBL ChEMBL 36 CHEMBL2095172

Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats GABA-A receptor; alpha-1/beta-2/gamma-2 as ChEMBL target CHEMBL2095172, mapped to UniProt P14867. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor

GABA-A receptor; alpha-1/beta-2/gamma-2

PROTEIN COMPLEX · Homo sapiens

As of 2026-09-13

ChEMBL target ID

CHEMBL2095172

Primary anchor for compounds, assays, approvals, and exports

ChEMBL 36 via Core Engine As of 2026-09-13

www.ebi.ac.uk

UniProt accession

P14867

Gamma-aminobutyric acid receptor subunit alpha-1

UniProt accession via ChEMBL component mapping As of 2026-09-13

www.uniprot.org

Disease evidence contract

Open Targets-ready proxy

ChEMBL drug mechanism + indication proxy

ChEMBL drug mechanism + indication proxy As of 2026-09-13

www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why GABA-A receptor; alpha-1/beta-2/gamma-2 matters

As of 2026-09-13

GABA-A receptor; alpha-1/beta-2/gamma-2 is reviewed as Gamma-aminobutyric acid receptor subunit alpha-1 (UniProt P14867); the current evidence base includes 14 approved drugs, 712 compounds, and 217 assays, with lead potency reaching pChEMBL 10.3.

Protein context

Gamma-aminobutyric acid receptor subunit alpha-1

Gamma-aminobutyric acid receptor subunit alpha-1 Sequence length is 456 aa.

Review this target as GABA-A receptor; alpha-1/beta-2/gamma-2, mapped to UniProt P14867. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit alpha-1. Sequence length is 456 aa.

Protein source · UniProt accession via ChEMBL component mapping

UniProt P14867 Protein

Disease context

Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record

Activity base

Portfolio and assay base

ChEMBL currently tracks 14 approved drugs, 712 compounds, and 217 assays for this target. The dominant activity type is EC50. CHEMBL1709464 is the current potency anchor at pChEMBL 10.3.

Use CHEMBL1709464 as the tractability anchor when discussing potency (pChEMBL 10.3).

Activity source · ChEMBL 36 via Core Engine

14 approved pChEMBL 10.3

Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?

Review-ready Target Rationale

One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why GABA-A receptor; alpha-1/beta-2/gamma-2 matters before drilling into raw source blocks.

Jump to Review Rationale

Need stable protein naming or accession mapping?

UniProt Target Context

UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P14867, not just the summarized rationale.

Open Protein Context

Need disease fit or evidence level for program framing?

Disease Relevance & Evidence Level

ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

712

Total Compounds

217

Total Assays

Approved Drugs

IC50: 111.0, KI: 84.0, EC50: 310.0

Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Compound	pChEMBL	Type	Phase
No preferred name CHEMBL1709464	10.3	Ki	—
No preferred name CHEMBL469477	9.9	Ki	—
No preferred name CHEMBL487686	9.9	Ki	—
No preferred name CHEMBL488283	9.9	Ki	—
No preferred name CHEMBL487687	9.8	Ki	—