Assay Detail
Binding
CHEMBL5142248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TDO (unknown origin) assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 75 mins by UV absorbance based analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.33 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355606 | — | — | 1 | 6.46 |
| CHEMBL39183 | — | — | 1 | 6.09 |
| CHEMBL274452 | — | — | 1 | 5.94 |
| CHEMBL5176579 | — | — | 1 | 5.94 |
| CHEMBL275224 | NORHARMANE | — | 1 | 5.92 |
| CHEMBL5186390 | — | — | 1 | 5.67 |
| CHEMBL5196062 | — | — | 1 | 5.27 |
| CHEMBL12014 | HARMAN | — | 1 | 5.20 |
| CHEMBL3975325 | — | — | 1 | 5.14 |
| CHEMBL5187479 | — | — | 1 | 5.08 |
| CHEMBL38596 | — | — | 1 | 4.96 |
| CHEMBL5195626 | — | — | 1 | 4.96 |
| CHEMBL5194494 | — | — | 1 | 4.92 |
| CHEMBL5180636 | — | — | 1 | 4.87 |
| CHEMBL5184595 | — | — | 1 | 4.81 |
| CHEMBL5188549 | — | — | 1 | 4.71 |
| CHEMBL5172850 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355606 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL39183 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL274452 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL5176579 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL275224 | NORHARMANE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5186390 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL5196062 | — | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL12014 | HARMAN | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL3975325 | — | IC50 | = | 7240.0 | nM | 5.14 |
| CHEMBL5187479 | — | IC50 | = | 8290.0 | nM | 5.08 |
| CHEMBL38596 | — | IC50 | = | 10840.0 | nM | 4.96 |
| CHEMBL5195626 | — | IC50 | = | 10920.0 | nM | 4.96 |
| CHEMBL5194494 | — | IC50 | = | 11980.0 | nM | 4.92 |
| CHEMBL5180636 | — | IC50 | = | 13390.0 | nM | 4.87 |
| CHEMBL5184595 | — | IC50 | = | 15330.0 | nM | 4.81 |
| CHEMBL5188549 | — | IC50 | = | 19510.0 | nM | 4.71 |
| CHEMBL5172850 | — | IC50 | = | 20290.0 | nM | 4.69 |