Assay Detail
Binding
CHEMBL5235566
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL2093872) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
β-Carboline as a Privileged Scaffold for Multitarget Strategies in Alzheimer's Disease Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.34 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747460 | — | — | 1 | 9.70 |
| CHEMBL1271047 | — | — | 1 | 9.40 |
| CHEMBL1518572 | — | — | 1 | 9.30 |
| CHEMBL49141 | — | — | 1 | 9.30 |
| CHEMBL5280240 | — | — | 1 | 9.30 |
| CHEMBL5290464 | — | — | 1 | 9.30 |
| CHEMBL5266498 | — | — | 1 | 9.30 |
| CHEMBL454095 | ABECARNIL | 2.0 | 1 | 9.00 |
| CHEMBL453066 | BETA-CCM | — | 1 | 9.00 |
| CHEMBL454606 | — | — | 1 | 9.00 |
| CHEMBL1337028 | — | — | 1 | 9.00 |
| CHEMBL509197 | — | — | 1 | 9.00 |
| CHEMBL5266558 | — | — | 1 | 8.52 |
| CHEMBL510764 | — | — | 1 | 8.52 |
| CHEMBL2262044 | — | — | 1 | 8.52 |
| CHEMBL499814 | — | — | 1 | 8.52 |
| CHEMBL5276119 | — | — | 1 | 8.40 |
| CHEMBL5290746 | — | — | 1 | 8.40 |
| CHEMBL457794 | — | — | 1 | 6.12 |
| CHEMBL275224 | NORHARMANE | — | 1 | 5.80 |
| CHEMBL12014 | HARMAN | — | 1 | 5.60 |
| CHEMBL1972187 | — | — | 1 | 4.51 |
| CHEMBL129208 | — | — | 1 | - |
| CHEMBL340807 | HARMALINE | — | 1 | - |
| CHEMBL269538 | HARMINE | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747460 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1271047 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1518572 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL49141 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5280240 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5290464 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5266498 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL454095 | ABECARNIL | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL453066 | BETA-CCM | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL454606 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1337028 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL509197 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5266558 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL510764 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2262044 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL499814 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5276119 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5290746 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL457794 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL275224 | NORHARMANE | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL12014 | HARMAN | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1972187 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL129208 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL340807 | HARMALINE | IC50 | > | 100.0 | microA | - |
| CHEMBL269538 | HARMINE | IC50 | > | 100000.0 | nM | - |