Compound Detail
CHEMBL454095
ABECARNIL 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL454095 |
| Name | ABECARNIL |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | RLFKILXOLJVUNF-UHFFFAOYSA-N |
11
Targets
17
Activities
3
Assay Types
0
PK Parameters
20
Publications
3
Known Names
Molecular Properties
404.5
MW (Da)
5.01
ALogP
5
HBA
1
HBD
73.4
PSA (Ų)
0.44
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
Ki 14 meas. best 9.0
Kd 2 meas. best 9.0
IC50 1 meas. best 9.0
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15646539 | 10.1016/s0399-8320(04)95062-2 | Unchecked | 11 |
| 15646539 | 10.1016/s0399-8320(04)95062-2 | NON-PROTEIN TARGET | 8 |
| 18537233 | 10.1021/jm701433b | Gamma-aminobutyric acid receptor subunit alpha-1 | 1 |
| 33528252 | 10.1021/acs.jmedchem.0c01887 | Gamma-aminobutyric acid receptor subunit alpha-6 | 1 |
| 33528252 | 10.1021/acs.jmedchem.0c01887 | Gamma-aminobutyric acid receptor subunit alpha-5 | 1 |
| 33528252 | 10.1021/acs.jmedchem.0c01887 | Gamma-aminobutyric acid receptor subunit alpha-4 | 1 |
| 33528252 | 10.1021/acs.jmedchem.0c01887 | Gamma-aminobutyric acid receptor subunit alpha-3 | 1 |
| 33528252 | 10.1021/acs.jmedchem.0c01887 | Gamma-aminobutyric acid receptor subunit alpha-2 | 1 |
| 33528252 | 10.1021/acs.jmedchem.0c01887 | Gamma-aminobutyric acid receptor subunit alpha-1 | 1 |
| 33528252 | 10.1021/acs.jmedchem.0c01887 | GABA-A receptor; anion channel | 1 |
| 18537233 | 10.1021/jm701433b | Gamma-aminobutyric acid receptor subunit alpha-5 | 1 |
| 10633039 | 10.1021/jm990341r | GABA-A receptor; alpha-1/beta-3/gamma-2 | 1 |
| 9651158 | 10.1021/jm970460b | GABA-A receptor; alpha-6/beta-3/gamma-2 | 1 |
| 9651158 | 10.1021/jm970460b | GABA-A receptor; alpha-5/beta-3/gamma-2 | 1 |
| 9651158 | 10.1021/jm970460b | GABA-A receptor; alpha-3/beta-3/gamma-2 | 1 |
| 9651158 | 10.1021/jm970460b | GABA-A receptor; alpha-2/beta-3/gamma-2 | 1 |
| 9651158 | 10.1021/jm970460b | GABA-A receptor; alpha-1/beta-3/gamma-2 | 1 |
| 10633039 | 10.1021/jm990341r | GABA-A receptor; alpha-6/beta-3/gamma-2 | 1 |
| 10633039 | 10.1021/jm990341r | GABA-A receptor; alpha-5/beta-3/gamma-2 | 1 |
| 10633039 | 10.1021/jm990341r | GABA-A receptor; alpha-3/beta-3/gamma-2 | 1 |
Data from ChEMBL 36 via Core Engine