Gamma-aminobutyric acid receptor subunit alpha-5 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P31644. Use UniProt P31644 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P31644 as the stable identity anchor, then attach disease evidence before program review.
Gamma-aminobutyric acid receptor subunit alpha-5
Review this target as Gamma-aminobutyric acid receptor subunit alpha-5, mapped to UniProt P31644. Sequence length is 462 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Gamma-aminobutyric acid receptor subunit alpha-5 as ChEMBL target CHEMBL5112, mapped to UniProt P31644. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Gamma-aminobutyric acid receptor subunit alpha-5 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P31644 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-aminobutyric acid receptor subunit alpha-5 |
| UniProt Accession | P31644 |
| Component Type | Protein |
| Sequence Length | 462 aa |
Gamma-aminobutyric acid receptor subunit alpha-5
Review this target as Gamma-aminobutyric acid receptor subunit alpha-5, mapped to UniProt P31644. Sequence length is 462 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3681588 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL3681586 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL3676421 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL3676424 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL3676425 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL3676426 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL3676436 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL3681585 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL5268764 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL3639753 | 9.4 | Ki | 0.4 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 38 | 488 | 8.0 |
| cell-based format | 8 | 10 | 6.8 |
| assay format | 2 | 11 | 7.8 |
| tissue-based format | 2 | 1 | 8.5 |