Compound Detail
CHEMBL5268764
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5268764 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BFKIZTLCAFUHPD-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
348.4
MW (Da)
2.27
ALogP
7
HBA
0
HBD
78.5
PSA (Ų)
0.53
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit alpha-5 CHEMBL5112 | Ki | 9.52 | 9.52 | 0.3 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 CHEMBL1962 | Ki | 9.4 | 9.4 | 0.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit alpha-5 | Ki | = | 0.3 | nM | 9.52 | Displacement of flumazenil from alpha5 GABAA receptor (unknown origin) | 36549396 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Ki | = | 0.4 | nM | 9.4 | Displacement of flumazenil from alpha1 GABAA receptor (unknown origin) | 36549396 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36549396 | 10.1016/j.bmcl.2022.129107 | Gamma-aminobutyric acid receptor subunit alpha-5 | 1 |
| 36549396 | 10.1016/j.bmcl.2022.129107 | Gamma-aminobutyric acid receptor subunit alpha-1 | 1 |
Data from ChEMBL 36 via Core Engine