Gamma-aminobutyric acid receptor subunit alpha-1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Gamma-aminobutyric acid receptor subunit alpha-1 shows late clinical disease relevance led by depressive disorder. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P14867. Start with depressive disorder, then reuse UniProt P14867 as the stable protein anchor across project notes and exports.
Start with depressive disorder, then reuse UniProt P14867 as the stable protein anchor across project notes and exports.
Gamma-aminobutyric acid receptor subunit alpha-1 shows late clinical disease relevance led by depressive disorder. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with depressive disorder because it currently carries late clinical support. Linked drugs include INDIPLON. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyGamma-aminobutyric acid receptor subunit alpha-1
Review this target as Gamma-aminobutyric acid receptor subunit alpha-1, mapped to UniProt P14867. Sequence length is 456 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Gamma-aminobutyric acid receptor subunit alpha-1 as ChEMBL target CHEMBL1962, mapped to UniProt P14867. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Gamma-aminobutyric acid receptor subunit alpha-1 is the right protein anchor across sources, using UniProt P14867 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why depressive disorder is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Gamma-aminobutyric acid receptor subunit alpha-1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P14867 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-aminobutyric acid receptor subunit alpha-1 |
| UniProt Accession | P14867 |
| Component Type | Protein |
| Sequence Length | 456 aa |
Gamma-aminobutyric acid receptor subunit alpha-1
Review this target as Gamma-aminobutyric acid receptor subunit alpha-1, mapped to UniProt P14867. Sequence length is 456 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Gamma-aminobutyric acid receptor subunit alpha-1 shows late clinical disease relevance led by depressive disorder. 1 more disease program remain visible in the same review block.
Start review with depressive disorder because it currently carries late clinical support. Linked drugs include INDIPLON. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3144739 | 10.0 | Kd | 0.1 | Preclinical |
| CHEMBL5280240 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL20042 | 9.52 | Kd | 0.3 | Preclinical |
| CHEMBL68684 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL5771253 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL5268764 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL49141 | 9.3 | Ki | 0.5 | Preclinical |
| CHEMBL1783256 | 9.3 | Ki | 0.5 | Preclinical |
| CHEMBL1783282 | 9.3 | Ki | 0.5 | Clinical |
| CHEMBL5266498 | 9.22 | Ki | 0.6 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 78 | 339 | 7.7 |
| cell-based format | 22 | 28 | 6.9 |
| tissue-based format | 2 | 1 | 7.4 |
| assay format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 0 | — |
| single protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 0 | — |