Compound Detail
CHEMBL1783256
AZD6280 Phase I
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Phase I
Basic Information
| ChEMBL ID | CHEMBL1783256 |
| Name | AZD6280 |
| Phase | Phase I |
| Structure Type | MOL |
| InChI Key | NVWCZRPXYVDQEE-UHFFFAOYSA-N |
5
Targets
6
Activities
1
Assay Types
1
PK Parameters
9
Publications
2
Known Names
1
Indications
2
Mechanisms
Molecular Properties
366.4
MW (Da)
3.04
ALogP
6
HBA
2
HBD
99.4
PSA (Ų)
0.70
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| GABA receptor alpha-2 subunit positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | Gamma-aminobutyric acid receptor subunit alpha-2 | ✓ | ✓ |
| GABA receptor alpha-3 subunit positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | Gamma-aminobutyric acid receptor subunit alpha-3 | ✓ | ✓ |
Indications
Anxiety
Activity Summary
Ki 6 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit alpha-1 CHEMBL1962 | Ki | 9.3 | 9.3 | 0.5 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 CHEMBL3026 | Ki | 8.51 | 8.51 | 3.1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 CHEMBL4956 | Ki | 8.3 | 8.06 | 5.0 | 2 |
| GABA-A receptor; alpha-2/beta-3/gamma-2 CHEMBL2094130 | Ki | 7.7 | 7.7 | 19.9 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 CHEMBL5112 | Ki | 5.78 | 5.78 | 1680.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 24.0 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit alpha-1 | Ki | = | 0.5 | nM | 9.3 | Binding affinity to GABA-A alpha1 (unknown origin) | 31738537 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Ki | = | 3.1 | nM | 8.51 | Binding affinity to GABA-A alpha3 (unknown origin) | 31738537 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Ki | = | 5.0 | nM | 8.3 | Binding affinity to GABA-A alpha2 (unknown origin) | 31738537 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Ki | = | 15.14 | nM | 7.82 | Binding affinity to GABA-A alpha2 (unknown origin) | 31738537 |
| GABA-A receptor; alpha-2/beta-3/gamma-2 | Ki | = | 19.95 | nM | 7.7 | Displacement of [3H]flunitrazepam from benzodiazepine binding site GABAA alpha2b... | 21498079 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Ki | = | 1680.0 | nM | 5.78 | Binding affinity to GABA-A alpha5 (unknown origin) | 31738537 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31738537 | 10.1021/acs.jmedchem.9b01312 | Gamma-aminobutyric acid receptor subunit alpha-2 | 3 |
| 21498079 | 10.1016/j.bmc.2011.03.035 | GABA-A receptor; alpha-2/beta-3/gamma-2 | 2 |
| 31738537 | 10.1021/acs.jmedchem.9b01312 | Gamma-aminobutyric acid receptor subunit alpha-1 | 2 |
| 31738537 | 10.1021/acs.jmedchem.9b01312 | Gamma-aminobutyric acid receptor subunit alpha-3 | 2 |
| 31738537 | 10.1021/acs.jmedchem.9b01312 | Gamma-aminobutyric acid receptor subunit alpha-5 | 2 |
| 21498079 | 10.1016/j.bmc.2011.03.035 | No relevant target | 1 |
| 21498079 | 10.1016/j.bmc.2011.03.035 | Liver microsomes | 1 |
| 21498079 | 10.1016/j.bmc.2011.03.035 | GABA-A receptor; alpha-1/beta-2/gamma-2 | 1 |
| 21498079 | 10.1016/j.bmc.2011.03.035 | GABA-A receptor; alpha-3/beta-3/gamma-2 | 1 |
Data from ChEMBL 36 via Core Engine