Assay Detail
Binding
CHEMBL5235569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human recombinant GABAA alpha3 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gamma-aminobutyric acid receptor subunit alpha-3 (CHEMBL3026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
β-Carboline as a Privileged Scaffold for Multitarget Strategies in Alzheimer's Disease Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.87 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301605 | — | — | 1 | 9.00 |
| CHEMBL49141 | — | — | 1 | 8.70 |
| CHEMBL5280240 | — | — | 1 | 8.70 |
| CHEMBL5275690 | — | — | 1 | 8.40 |
| CHEMBL5290579 | — | — | 1 | 8.40 |
| CHEMBL454095 | ABECARNIL | 2.0 | 1 | 8.40 |
| CHEMBL5266498 | — | — | 1 | 8.30 |
| CHEMBL454606 | — | — | 1 | 8.22 |
| CHEMBL1518572 | — | — | 1 | 8.22 |
| CHEMBL497197 | — | — | 1 | 7.96 |
| CHEMBL5290464 | — | — | 1 | 7.96 |
| CHEMBL2008708 | — | — | 1 | 7.80 |
| CHEMBL509197 | — | — | 1 | 7.72 |
| CHEMBL510764 | — | — | 1 | 7.68 |
| CHEMBL496990 | — | — | 1 | 7.62 |
| CHEMBL5281056 | — | — | 1 | 7.51 |
| CHEMBL5290746 | — | — | 1 | 7.31 |
| CHEMBL499814 | — | — | 1 | 7.16 |
| CHEMBL453066 | BETA-CCM | — | 1 | 7.14 |
| CHEMBL1270038 | — | — | 1 | 7.00 |
| CHEMBL1270841 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301605 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL49141 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL5280240 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL5275690 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL5290579 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL454095 | ABECARNIL | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL5266498 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL454606 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL1518572 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL497197 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL5290464 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL2008708 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL509197 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL510764 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL496990 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL5281056 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL5290746 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL499814 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL453066 | BETA-CCM | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL1270038 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1270841 | — | Ki | = | 1000.0 | nM | 6.00 |