Assay Detail
Binding
CHEMBL651677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for rat benzodiazepine receptor inverse agonist site
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Comparative molecular moment analysis (CoMMA): 3D-QSAR without molecular superposition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.76 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3144739 | — | — | 1 | 10.00 |
| CHEMBL19732 | CGS-8216 | — | 1 | 9.40 |
| CHEMBL20042 | CGS-9896 | — | 1 | 9.22 |
| CHEMBL69719 | — | — | 1 | 8.55 |
| CHEMBL301605 | — | — | 1 | 8.40 |
| CHEMBL11709 | — | — | 1 | 8.30 |
| CHEMBL307783 | — | — | 1 | 8.00 |
| CHEMBL66273 | — | — | 1 | 8.00 |
| CHEMBL52750 | — | — | 1 | 7.96 |
| CHEMBL299250 | — | — | 1 | 7.62 |
| CHEMBL298561 | — | — | 1 | 7.35 |
| CHEMBL66274 | — | — | 1 | 7.08 |
| CHEMBL66902 | — | — | 1 | 7.01 |
| CHEMBL54228 | — | — | 1 | 6.91 |
| CHEMBL53229 | — | — | 1 | 6.90 |
| CHEMBL69336 | — | — | 1 | 6.80 |
| CHEMBL304273 | — | — | 1 | 6.65 |
| CHEMBL69488 | — | — | 1 | 6.61 |
| CHEMBL67774 | — | — | 1 | 6.60 |
| CHEMBL67421 | — | — | 1 | 6.30 |
| CHEMBL66487 | — | — | 1 | 6.17 |
| CHEMBL302056 | — | — | 1 | 6.15 |
| CHEMBL67951 | — | — | 1 | 6.12 |
| CHEMBL299060 | — | — | 1 | 5.93 |
| CHEMBL275224 | NORHARMANE | — | 1 | 5.79 |
| CHEMBL55630 | — | — | 1 | 5.77 |
| CHEMBL69282 | — | — | 1 | 5.72 |
| CHEMBL53230 | — | — | 1 | 5.71 |
| CHEMBL66841 | — | — | 1 | 5.62 |
| CHEMBL303932 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3144739 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL19732 | CGS-8216 | IC50 | = | 0.3999 | nM | 9.40 |
| CHEMBL20042 | CGS-9896 | IC50 | = | 0.5998 | nM | 9.22 |
| CHEMBL69719 | — | IC50 | = | 2.799 | nM | 8.55 |
| CHEMBL301605 | — | IC50 | = | 3.999 | nM | 8.40 |
| CHEMBL11709 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL307783 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL66273 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL52750 | — | IC50 | = | 11.02 | nM | 7.96 |
| CHEMBL299250 | — | IC50 | = | 23.99 | nM | 7.62 |
| CHEMBL298561 | — | IC50 | = | 44.98 | nM | 7.35 |
| CHEMBL66274 | — | IC50 | = | 82.99 | nM | 7.08 |
| CHEMBL66902 | — | IC50 | = | 97.95 | nM | 7.01 |
| CHEMBL54228 | — | IC50 | = | 123.88 | nM | 6.91 |
| CHEMBL53229 | — | IC50 | = | 125.03 | nM | 6.90 |
| CHEMBL69336 | — | IC50 | = | 157.04 | nM | 6.80 |
| CHEMBL304273 | — | IC50 | = | 223.87 | nM | 6.65 |
| CHEMBL69488 | — | IC50 | = | 244.91 | nM | 6.61 |
| CHEMBL67774 | — | IC50 | = | 250.03 | nM | 6.60 |
| CHEMBL67421 | — | IC50 | = | 500.03 | nM | 6.30 |
| CHEMBL66487 | — | IC50 | = | 680.77 | nM | 6.17 |
| CHEMBL302056 | — | IC50 | = | 714.5 | nM | 6.15 |
| CHEMBL67951 | — | IC50 | = | 749.89 | nM | 6.12 |
| CHEMBL299060 | — | IC50 | = | 1164.13 | nM | 5.93 |
| CHEMBL275224 | NORHARMANE | IC50 | = | 1621.81 | nM | 5.79 |
| CHEMBL55630 | — | IC50 | = | 1698.24 | nM | 5.77 |
| CHEMBL69282 | — | IC50 | = | 1918.67 | nM | 5.72 |
| CHEMBL53230 | — | IC50 | = | 1972.42 | nM | 5.71 |
| CHEMBL66841 | — | IC50 | = | 2398.83 | nM | 5.62 |
| CHEMBL303932 | — | IC50 | = | 5000.35 | nM | 5.30 |
| CHEMBL69006 | — | IC50 | = | 6854.88 | nM | 5.16 |
| CHEMBL12063 | — | IC50 | = | 7533.56 | nM | 5.12 |
| CHEMBL70086 | — | IC50 | = | 9204.5 | nM | 5.04 |
| CHEMBL12014 | HARMAN | IC50 | = | 12387.97 | nM | 4.91 |
| CHEMBL67772 | — | IC50 | = | 26001.6 | nM | 4.58 |
| CHEMBL441986 | — | IC50 | = | 250034.54 | nM | - |