Compound Detail
CHEMBL69006
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Basic Information
| ChEMBL ID | CHEMBL69006 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FLUGPFWFCCQUNR-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
271.3
MW (Da)
4.61
ALogP
1
HBA
2
HBD
44.5
PSA (Ų)
0.42
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; anion channel CHEMBL1907607 | IC50 | 5.16 | 5.16 | 6854.9 | 3 |
| GABA-A receptor; anion channel CHEMBL2093872 | IC50 | 5.16 | 5.16 | 6918.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | IC50 | = | 6854.88 | nM | 5.16 | Binding affinity for rat benzodiazepine receptor inverse agonist site | 8667357 |
| GABA-A receptor; anion channel | IC50 | = | 6854.88 | nM | 5.16 | Binding affinity towards benzodiazepine receptor inverse agonist site by the dis... | 8411009 |
| GABA-A receptor; anion channel | IC50 | = | 6918.31 | nM | 5.16 | Inhibition on Benzodiazepine receptor | 9435905 |
| GABA-A receptor; anion channel | IC50 | = | 6860.0 | nM | 5.16 | In vitro inhibition of 3[H]Diazepam binding to Benzodiazepine receptor from rat ... | 2167977 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8667357 | 10.1021/jm950589q | GABA-A receptor; anion channel | 1 |
| 8411009 | 10.1021/jm00072a012 | GABA-A receptor; anion channel | 1 |
| 9435905 | 10.1021/jm970488n | GABA-A receptor; anion channel | 1 |
| 2167977 | 10.1021/jm00171a007 | GABA-A receptor; anion channel | 1 |
Data from ChEMBL 36 via Core Engine