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Assay Detail

CHEMBL1017749

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Toxicity against human dermal fibroblasts
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Cell Type Fibroblast
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Synthesis and in vitro biological activity of retinyl polyhydroxybenzoates, novel hybrid retinoid derivatives.
Kim S, Kim Y, Kong Y, Kim H, Kang J.
Bioorg Med Chem Lett (2009) 19 : 508 -512
PubMed 19036585 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.76 5.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL169 URSOLIC ACID 2.0 1 5.46
CHEMBL467400 1 4.85
CHEMBL513502 1 4.85
CHEMBL459327 1 4.85
CHEMBL456687 1 4.57
CHEMBL459533 1 4.46
CHEMBL986 RETINOL 4.0 1 4.30
CHEMBL511175 1 -
CHEMBL456686 1 -
CHEMBL514133 1 -
CHEMBL459287 1 -
CHEMBL511230 1 -
CHEMBL467749 1 -
CHEMBL468793 1 -
CHEMBL468794 1 -
CHEMBL165 RESVERATROL 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL169 URSOLIC ACID IC50 = 3500.0 nM 5.46
CHEMBL467400 IC50 = 14000.0 nM 4.85
CHEMBL513502 IC50 = 14000.0 nM 4.85
CHEMBL459327 IC50 = 14000.0 nM 4.85
CHEMBL456687 IC50 = 27000.0 nM 4.57
CHEMBL459533 IC50 = 35000.0 nM 4.46
CHEMBL986 RETINOL IC50 = 50000.0 nM 4.30
CHEMBL511175 IC50 = 150000.0 nM -
CHEMBL456686 IC50 = 150000.0 nM -
CHEMBL514133 IC50 < 10000.0 nM -
CHEMBL459287 IC50 = 120000.0 nM -
CHEMBL511230 IC50 = 570000.0 nM -
CHEMBL467749 IC50 = 420000.0 nM -
CHEMBL468793 IC50 = 230000.0 nM -
CHEMBL468794 IC50 < 10000.0 nM -
CHEMBL165 RESVERATROL IC50 = 900000.0 nM -