Assay Detail
Binding
CHEMBL1018105
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Inhibition of Jak3
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.95 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL459044 | — | — | 1 | 7.13 |
| CHEMBL458333 | — | — | 1 | 6.77 |
| CHEMBL502156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL459044 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL458333 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL502156 | — | Ki | > | 12500.0 | nM | - |