Assay Detail
Binding
CHEMBL1018146
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Inhibition of GST-IGF1R
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 7.16 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447167 | — | — | 1 | 8.05 |
| CHEMBL461662 | — | — | 1 | 8.00 |
| CHEMBL453681 | — | — | 1 | 7.96 |
| CHEMBL505519 | — | — | 1 | 7.89 |
| CHEMBL512412 | — | — | 1 | 7.85 |
| CHEMBL447951 | — | — | 1 | 7.85 |
| CHEMBL498816 | — | — | 1 | 7.82 |
| CHEMBL499661 | — | — | 1 | 7.80 |
| CHEMBL504954 | — | — | 1 | 7.80 |
| CHEMBL442912 | — | — | 1 | 7.77 |
| CHEMBL504929 | — | — | 1 | 7.70 |
| CHEMBL503167 | — | — | 1 | 7.70 |
| CHEMBL457421 | — | — | 1 | 7.62 |
| CHEMBL504379 | — | — | 1 | 7.58 |
| CHEMBL467438 | — | — | 1 | 7.58 |
| CHEMBL468700 | — | — | 1 | 7.52 |
| CHEMBL469294 | — | — | 1 | 7.52 |
| CHEMBL469295 | — | — | 1 | 7.51 |
| CHEMBL448967 | — | — | 1 | 7.50 |
| CHEMBL448243 | — | — | 1 | 7.35 |
| CHEMBL501359 | — | — | 1 | 7.33 |
| CHEMBL103045 | — | — | 1 | 7.30 |
| CHEMBL463619 | — | — | 1 | 7.19 |
| CHEMBL318804 | — | — | 1 | 7.18 |
| CHEMBL502423 | — | — | 1 | 7.17 |
| CHEMBL460377 | — | — | 1 | 7.10 |
| CHEMBL323515 | — | — | 1 | 7.06 |
| CHEMBL507862 | — | — | 1 | 6.87 |
| CHEMBL460164 | — | — | 1 | 6.85 |
| CHEMBL512088 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447167 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL461662 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL453681 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL505519 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL512412 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL447951 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL498816 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL499661 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL504954 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL442912 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL503167 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL504929 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL457421 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL504379 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL467438 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL468700 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL469294 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL469295 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL448967 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL448243 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL501359 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL103045 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL463619 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL318804 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL502423 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL460377 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL323515 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL507862 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL460164 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL512088 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL512813 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL460165 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL447581 | — | IC50 | = | 291.0 | nM | 6.54 |
| CHEMBL468907 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL467232 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL468269 | — | IC50 | = | 847.0 | nM | 6.07 |
| CHEMBL322857 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL461015 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL443410 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL444223 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL318326 | — | IC50 | > | 10000.0 | nM | - |