Assay Detail
Binding
CHEMBL1018831
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of VDR in human THP1 cells assessed as increase in cathelicidin antimicrobial peptide mRNA expression by RT-PCR
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.78 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494338 | — | — | 1 | 9.17 |
| CHEMBL492749 | — | — | 1 | 9.16 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494338 | — | EC50 | = | 0.68 | nM | 9.17 |
| CHEMBL492749 | — | EC50 | = | 0.69 | nM | 9.16 |
| CHEMBL846 | CALCITRIOL | EC50 | = | 10.0 | nM | 8.00 |