Assay Detail
Functional
CHEMBL1018859
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human EOL-1 cells after 72 hrs by alamar-blue cell viability assay
12
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EOL1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.70 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL941 | IMATINIB | 4.0 | 2 | 9.70 |
| CHEMBL473825 | — | — | 1 | 8.52 |
| CHEMBL1080580 | — | — | 1 | 8.22 |
| CHEMBL475820 | — | — | 1 | 8.15 |
| CHEMBL514671 | — | — | 1 | 7.28 |
| CHEMBL475796 | — | — | 2 | 7.00 |
| CHEMBL514351 | — | — | 2 | 6.96 |
| CHEMBL474863 | — | — | 1 | 6.92 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL941 | IMATINIB | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL941 | IMATINIB | IC50 | = | 0.1995 | nM | 9.70 |
| CHEMBL473825 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1080580 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL475820 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL514671 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL475796 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL475796 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL514351 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL474863 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL514351 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1000.0 | nM | 6.00 |