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Target Snapshot

CHEMBL614489 Target Snapshot

EOL1 · CELL-LINE · Homo sapiens

302Compounds
169Assays
28Approved Drugs
223.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats EOL1 as ChEMBL target CHEMBL614489. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
EOL1
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614489
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether EOL1 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelEOL1
UniProt AccessionN/A

EOL1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as EOL1.

Review nameEOL1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

28
Approved
15
Phase III
10
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC50209.0
EC5014.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5416410 10.88 IC50 0.01309 Approved
CHEMBL5289142 10.7 IC50 0.02 Preclinical
CHEMBL477772 10.54 IC50 0.02889 Approved
CHEMBL2041933 10.44 IC50 0.03656 Preclinical
CHEMBL1289926 10.29 IC50 0.05132 Approved
CHEMBL255863 9.84 IC50 0.1445 Approved
CHEMBL941 9.7 IC50 0.1995 Approved
CHEMBL65 9.57 IC50 0.2708 Preclinical
CHEMBL888 9.21 IC50 0.6162 Approved
CHEMBL572881 9.03 IC50 0.9439 Clinical
Distribution

pChEMBL Value Distribution

24
5.0
27
5.5
29
6.0
20
6.5
17
7.0
11
7.5
10
8.0
7
8.5
2
9.0
4
9.5
pChEMBL
Approved Drugs

Approved Drugs

SELUMETINIB
CHEMBL1614701
Approved 2020
MIDOSTAURIN
CHEMBL608533
Approved 2017
VENETOCLAX
CHEMBL3137309
Approved 2016
PALBOCICLIB
CHEMBL189963
Approved 2015
OLAPARIB
CHEMBL521686
Approved 2014
AFATINIB
CHEMBL1173655
Approved 2013
AXITINIB
CHEMBL1289926
Approved 2012
BOSUTINIB
CHEMBL288441
Approved 2012
PAZOPANIB
CHEMBL477772
Approved 2009
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
NILOTINIB
CHEMBL255863
Approved 2007
DASATINIB
CHEMBL5416410
Approved 2006
VORINOSTAT
CHEMBL98
Approved 2006
GEFITINIB
CHEMBL939
Approved 2003
IMATINIB
CHEMBL941
Approved 2001
SIROLIMUS
CHEMBL413
Approved 1999
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
ETOPOSIDE
CHEMBL44657
Approved 1983
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

169
Total Assays
195
Tested Compounds
1
Assay Types
Functional — 169 assays, 195 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 156 195 6.4
organism-based format 13 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine