Compound Detail

CHEMBL572881

MOTESANIB

🧪 Phase III

Enter ChEMBL ID:

Free Research Context This compound will appear in recent viewed items on the research home for this browser.

Research home View demo workspace

🧪 Phase III

CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL572881
Name	MOTESANIB
Phase	Phase III
Structure Type	MOL
InChI Key	RAHBGWKEPAQNFF-UHFFFAOYSA-N

Known Names

AMG 706 AMG-706 Motesanib

395

Targets

727

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Mechanisms

Molecular Properties

373.5

MW (Da)

4.04

ALogP

HBA

HBD

78.9

PSA (Å²)

0.63

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
Chirality	Achiral

Flags

Natural Product

USAN Stem	-anib
USAN Year	2005

Extended Properties

Molecular Formula	C22H23N5O
MW	373.46
Aromatic Rings	3
Heavy Atoms	28
NP-Likeness	-0.95

Mechanism of Action

Mechanism	Action Type	Target	Direct	Efficacy
Stem cell growth factor receptor inhibitor	INHIBITOR	Mast/stem cell growth factor receptor Kit	✓	✓
Tyrosine-protein kinase receptor RET inhibitor	INHIBITOR	Proto-oncogene tyrosine-protein kinase receptor Ret	✓	✓
Vascular endothelial growth factor receptor inhibitor	INHIBITOR	Vascular endothelial growth factor receptor	✓	✓
Platelet-derived growth factor receptor inhibitor	INHIBITOR	Platelet-derived growth factor receptor	✓	✓

Indications

Carcinoma, Non-Small-Cell Lung Breast Neoplasms

Activity Summary

IC50 600 meas. best 9.03

Kd 126 meas. best 9.0

Ki 1 meas. best 8.52

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
EOL1 CHEMBL614489	IC50	9.03	9.03	0.9	1
Mitogen-activated protein kinase kinase kinase kinase 1 CHEMBL5749	Kd	9.0	9.0	1.0	1
Mast/stem cell growth factor receptor Kit CHEMBL1936	Kd	8.89	7.7307	1.3	15
Vascular endothelial growth factor receptor 1 CHEMBL1868	IC50	8.7	8.7	2.0	4
Vascular endothelial growth factor receptor 2 CHEMBL279	IC50	8.52	8.52	3.0	5
Vascular endothelial growth factor receptor 2 CHEMBL279	Ki	8.52	8.52	3.0	1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B CHEMBL4105974	Kd	8.52	8.52	3.0	1
Macrophage colony-stimulating factor 1 receptor CHEMBL1844	Kd	8.25	8.25	5.6	2
Vascular endothelial growth factor receptor 3 CHEMBL1955	IC50	8.22	8.22	6.0	3
Vascular endothelial growth factor receptor 2 CHEMBL3337	IC50	8.22	8.22	6.0	1
Mast/stem cell growth factor receptor Kit CHEMBL1936	IC50	8.1	8.1	8.0	1
Mitogen-activated protein kinase kinase kinase 20 CHEMBL3886	Kd	8.1	7.71	8.0	3
Platelet-derived growth factor receptor beta CHEMBL1913	Kd	8.04	8.04	9.1	2
Vascular endothelial growth factor receptor 3 CHEMBL1955	Kd	8.01	8.01	9.7	2
Platelet-derived growth factor receptor alpha CHEMBL2007	Kd	8.0	8.0	10.0	2
HUVEC CHEMBL613979	IC50	8.0	8.0	10.0	1
Vascular endothelial growth factor receptor 1 CHEMBL1868	Kd	7.92	7.92	12.0	2
Proto-oncogene tyrosine-protein kinase receptor Ret CHEMBL2041	Kd	7.85	7.638	14.0	5
Epidermal growth factor receptor CHEMBL203	Kd	7.82	5.7563	15.0	16
Vascular endothelial growth factor receptor 2 CHEMBL279	Kd	7.58	7.58	26.0	2
Unchecked CHEMBL612545	IC50	7.43	5.2948	37.0	21
Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974	Kd	7.27	6.0573	54.0	11
Proto-oncogene tyrosine-protein kinase receptor Ret CHEMBL2041	IC50	7.23	7.1533	59.0	3
Tyrosine-protein kinase FRK CHEMBL4223	Kd	7.0	7.0	99.0	3
Tyrosine-protein kinase Lyn CHEMBL3905	Kd	6.8	6.8	160.0	2
Mitogen-activated protein kinase kinase kinase 19 CHEMBL6191	Kd	6.7	6.7	200.0	1
Serine/threonine-protein kinase TNNI3K CHEMBL5260	Kd	6.66	6.66	220.0	2
Epithelial discoidin domain-containing receptor 1 CHEMBL5319	Kd	6.58	6.58	260.0	2
Serine/threonine-protein kinase B-raf CHEMBL5145	Kd	6.55	6.375	280.0	4
Citron Rho-interacting kinase CHEMBL5579	Kd	6.52	6.52	300.0	2
Tyrosine-protein kinase Lck CHEMBL258	Kd	6.44	6.44	360.0	2
DU-145 CHEMBL613508	IC50	6.33	6.33	469.4	1
Ephrin type-A receptor 6 CHEMBL4526	Kd	6.31	6.31	490.0	2
A204 CHEMBL614514	IC50	6.29	6.29	518.5	1
SK-N-DZ CHEMBL1075579	IC50	6.26	6.26	549.0	1
Tyrosine-protein kinase ABL1 CHEMBL1862	Kd	6.17	5.63	670.0	9
CGTH-W-1 CHEMBL2366300	IC50	6.17	6.17	670.0	1
NCI-H1648 CHEMBL2366214	IC50	6.16	6.16	685.6	1
RAF proto-oncogene serine/threonine-protein kinase CHEMBL1906	Kd	6.06	6.06	880.0	2
Protein-tyrosine kinase 6 CHEMBL4601	Kd	6.0	6.0	1000.0	2
G-402 CHEMBL1075446	IC50	5.99	5.99	1018.5	1
Receptor-interacting serine/threonine-protein kinase 3 CHEMBL1795199	Kd	5.98	5.98	1044.0	1
Serine/threonine-protein kinase 10 CHEMBL3981	Kd	5.96	5.96	1100.0	2
STE20-like serine/threonine-protein kinase CHEMBL4202	Kd	5.89	5.89	1300.0	2
Mitogen-activated protein kinase kinase kinase 7 CHEMBL5776	Kd	5.89	5.89	1300.0	1
RT-112 CHEMBL614145	IC50	5.8	5.8	1585.5	1
Aurora kinase C CHEMBL3935	Kd	5.72	5.72	1900.0	2
Mitogen-activated protein kinase kinase kinase 3 CHEMBL5970	Kd	5.68	5.68	2100.0	1
Tyrosine-protein kinase Blk CHEMBL2250	Kd	5.66	5.66	2200.0	2
NB10 CHEMBL2366243	IC50	5.63	5.63	2350.5	1

Pharmacokinetic Data

Parameter	Value	Units	Species
AUC	1800.0	ng.hr.mL-1	Rattus norvegicus
AUC	5000.0	ng.hr.mL-1	Rattus norvegicus
Cmax	615.86	nM	Rattus norvegicus
Cmax	5623.09	nM	Rattus norvegicus

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
EOL1	IC50	=	0.9439	nM	9.03	SANGER: Inhibition of human EoL-1-cell cell growth in a cell viability assay.	-
Mitogen-activated protein kinase kinase kinase kinase 1	Kd	=	1.0	nM	9.0	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase ...	29191878
Mast/stem cell growth factor receptor Kit	Kd	=	1.3	nM	8.89	Binding constant for KIT(L576P) kinase domain	22037378
Vascular endothelial growth factor receptor 1	IC50	=	2.0	nM	8.7	Inhibition of VEGFR1	23098265
Vascular endothelial growth factor receptor 1	IC50	=	2.0	nM	8.7	Inhibition of VEGFR1 (unknown origin)	26881908
Vascular endothelial growth factor receptor 1	IC50	=	2.0	nM	8.7	Inhibition of VEGFR1 (unknown origin)	34351741
Vascular endothelial growth factor receptor 1	IC50	=	2.0	nM	8.7	Inhibition of VEGFR1 (unknown origin) using gastrin peptide as substrate and ATP...	16951187
Vascular endothelial growth factor receptor 2	Ki	=	3.0	nM	8.52	In-Vitro Kinase Inhibition Assay: Compounds 2-4 and cabozantinib were each teste...	-
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Kd	=	3.0	nM	8.52	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase ...	29191878
Vascular endothelial growth factor receptor 2	IC50	=	3.0	nM	8.52	Inhibition of VEGFR2 (unknown origin) using gastrin peptide as substrate and ATP...	16951187
Vascular endothelial growth factor receptor 2	IC50	=	3.0	nM	8.52	Inhibition of VEGFR2 (unknown origin)	34351741
Vascular endothelial growth factor receptor 2	IC50	=	3.0	nM	8.52	Inhibition of VEGFR2 (unknown origin)	26881908
Vascular endothelial growth factor receptor 2	IC50	=	3.0	nM	8.52	Inhibition of VEGFR2	23098265
Vascular endothelial growth factor receptor 2	IC50	=	3.0	nM	8.52	Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assay	20869793
Mast/stem cell growth factor receptor Kit	Kd	=	3.2	nM	8.49	Binding constant for KIT(V559D) kinase domain	18183025
Mast/stem cell growth factor receptor Kit	Kd	=	3.2	nM	8.49	Binding constant for KIT(V559D) kinase domain	22037378
Mast/stem cell growth factor receptor Kit	Kd	=	3.7	nM	8.43	Binding constant for KIT kinase domain	22037378
Mast/stem cell growth factor receptor Kit	Kd	=	3.7	nM	8.43	Binding affinity to human KIT incubated for 1 hr by kinase binding assay	21429632
Mast/stem cell growth factor receptor Kit	Kd	=	3.7	nM	8.43	Binding constant for KIT kinase domain	18183025
Macrophage colony-stimulating factor 1 receptor	Kd	=	5.6	nM	8.25	Binding constant for CSF1R kinase domain	22037378

Literature References

PubMed	DOI	Target Context	# Activities
26254279	10.18632/oncotarget.4214	Unchecked	27
22037378	10.1038/nbt.1990	Tyrosine-protein kinase ABL1	15
22037378	10.1038/nbt.1990	Epidermal growth factor receptor	12
16951187	10.1158/0008-5472.can-05-4665	A-431	12
22037378	10.1038/nbt.1990	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	10
18183025	10.1038/nbt1358	Epidermal growth factor receptor	10
22037378	10.1038/nbt.1990	Mast/stem cell growth factor receptor Kit	8
22037378	10.1038/nbt.1990	Receptor-type tyrosine-protein kinase FLT3	7
18183025	10.1038/nbt1358	Tyrosine-protein kinase ABL1	7
16951187	10.1158/0008-5472.can-05-4665	Unchecked	7
18183025	10.1038/nbt1358	Receptor-type tyrosine-protein kinase FLT3	5
16951187	10.1158/0008-5472.can-05-4665	ADMET	5
29191878	10.1126/science.aan4368	Unchecked	5
18183025	10.1038/nbt1358	Mast/stem cell growth factor receptor Kit	5
-	10.6019/CHEMBL4495565	SARS-CoV-2	4
22037378	10.1038/nbt.1990	Proto-oncogene tyrosine-protein kinase receptor Ret	4
-	10.6019/CHEMBL4808148	Histone deacetylase 6	3
22037378	10.1038/nbt.1990	Hepatocyte growth factor receptor	3
16951187	10.1158/0008-5472.can-05-4665	Rattus norvegicus	3
18183025	10.1038/nbt1358	Vascular endothelial growth factor receptor 2	2

Data from ChEMBL 36 via Core Engine