Assay Detail
Binding
CHEMBL2186468
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Inhibition of VEGFR2
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.15 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1289494 | TIVOZANIB | 4.0 | 1 | 9.80 |
| CHEMBL2180604 | TAK-593 | 1.0 | 1 | 9.02 |
| CHEMBL491473 | CEDIRANIB | 3.0 | 1 | 9.00 |
| CHEMBL572881 | MOTESANIB | 3.0 | 1 | 8.52 |
| CHEMBL1289601 | LENVATINIB | 4.0 | 1 | 8.40 |
| CHEMBL2180602 | TAFETINIB | 1.0 | 1 | 8.30 |
| CHEMBL2079588 | TELATINIB | 2.0 | 1 | 8.22 |
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 8.17 |
| CHEMBL1614710 | OSI-930 | 1.0 | 1 | 8.05 |
| CHEMBL253969 | OSI-632 | 2.0 | 1 | 7.96 |
| CHEMBL2180605 | — | — | 1 | 7.60 |
| CHEMBL2180603 | — | — | 1 | 7.50 |
| CHEMBL101253 | VATALANIB | 3.0 | 1 | 7.37 |
| CHEMBL352308 | — | — | 1 | 7.16 |
| CHEMBL587723 | AEE-788 | 2.0 | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1289494 | TIVOZANIB | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL2180604 | TAK-593 | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL491473 | CEDIRANIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1289601 | LENVATINIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2180602 | TAFETINIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2079588 | TELATINIB | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1230609 | FORETINIB | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL1614710 | OSI-930 | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL253969 | OSI-632 | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2180605 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2180603 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL101253 | VATALANIB | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL352308 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL587723 | AEE-788 | IC50 | = | 77.0 | nM | 7.11 |