Compound Detail
CHEMBL352308
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Basic Information
| ChEMBL ID | CHEMBL352308 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VQCDZFWRGXFUMS-UHFFFAOYSA-N |
5
Targets
8
Activities
1
Assay Types
0
PK Parameters
14
Publications
0
Known Names
Molecular Properties
501.6
MW (Da)
6.04
ALogP
7
HBA
3
HBD
84.9
PSA (Ų)
0.22
QED
2
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 8 meas. best 7.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 7.16 | 7.16 | 69.0 | 1 |
| Mast/stem cell growth factor receptor Kit CHEMBL1936 | IC50 | 7.16 | 7.08 | 69.0 | 2 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.16 | 7.12 | 69.0 | 2 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 7.16 | 7.11 | 69.0 | 2 |
| Platelet-derived growth factor receptor CHEMBL2095189 | IC50 | 6.32 | 6.32 | 480.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta | IC50 | = | 69.0 | nM | 7.16 | Inhibition of PDGFRbeta | 23098265 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 69.0 | nM | 7.16 | Inhibition of c-Kit | 23098265 |
| Fibroblast growth factor receptor 2 | IC50 | = | 69.0 | nM | 7.16 | Inhibition of FGFR2 | 23098265 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 69.0 | nM | 7.16 | Inhibition of VEGFR2 | 23098265 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 83.0 | nM | 7.08 | Inhibition of vascular endothelial growth factor receptor 2 autophosphorylation ... | 15012985 |
| Fibroblast growth factor receptor 2 | IC50 | = | 88.0 | nM | 7.06 | In vitro inhibition against autophosphorylation of Fibroblast growth factor rece... | 15012985 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 100.0 | nM | 7.0 | Inhibition of c-Kit autophosphorylation in intact cells | 15012985 |
| Platelet-derived growth factor receptor | IC50 | = | 480.0 | nM | 6.32 | Inhibition of PDGF-receptor autophosphorylation in intact cells | 15012985 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15012985 | 10.1016/j.bmcl.2003.12.019 | Rattus norvegicus | 2 |
| 15012985 | 10.1016/j.bmcl.2003.12.019 | Homo sapiens | 2 |
| 15012985 | 10.1016/j.bmcl.2003.12.019 | No relevant target | 2 |
| 15012985 | 10.1016/j.bmcl.2003.12.019 | Epidermal growth factor receptor | 2 |
| 15012985 | 10.1016/j.bmcl.2003.12.019 | Insulin-like growth factor 1 receptor | 2 |
| 15012985 | 10.1016/j.bmcl.2003.12.019 | Hepatocyte growth factor receptor | 2 |
| 15012985 | 10.1016/j.bmcl.2003.12.019 | Fibroblast growth factor receptor 2 | 1 |
| 15012985 | 10.1016/j.bmcl.2003.12.019 | Vascular endothelial growth factor receptor 2 | 1 |
| 15012985 | 10.1016/j.bmcl.2003.12.019 | Platelet-derived growth factor receptor | 1 |
| 15012985 | 10.1016/j.bmcl.2003.12.019 | Mast/stem cell growth factor receptor Kit | 1 |
| 23098265 | 10.1021/jm301085w | Platelet-derived growth factor receptor beta | 1 |
| 23098265 | 10.1021/jm301085w | Mast/stem cell growth factor receptor Kit | 1 |
| 23098265 | 10.1021/jm301085w | Fibroblast growth factor receptor 2 | 1 |
| 23098265 | 10.1021/jm301085w | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine