Assay Detail
Binding
CHEMBL2186463
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-Kit
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.82 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180602 | TAFETINIB | 1.0 | 1 | 8.30 |
| CHEMBL1614710 | OSI-930 | 1.0 | 1 | 8.00 |
| CHEMBL352308 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180602 | TAFETINIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1614710 | OSI-930 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL352308 | — | IC50 | = | 69.0 | nM | 7.16 |