Assay Detail
Binding
CHEMBL678691
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In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Orally active anti-proliferation agents: novel diphenylamine derivatives as FGF-R2 autophosphorylation inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.67 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL171509 | — | — | 1 | 7.64 |
| CHEMBL170519 | — | — | 1 | 7.40 |
| CHEMBL169837 | — | — | 1 | 7.27 |
| CHEMBL170907 | — | — | 1 | 7.20 |
| CHEMBL354898 | — | — | 1 | 7.16 |
| CHEMBL414643 | — | — | 1 | 7.15 |
| CHEMBL168335 | — | — | 1 | 7.15 |
| CHEMBL352308 | — | — | 1 | 7.06 |
| CHEMBL169854 | — | — | 1 | 7.00 |
| CHEMBL167425 | — | — | 1 | 6.89 |
| CHEMBL171413 | — | — | 1 | 6.72 |
| CHEMBL354902 | — | — | 1 | 6.70 |
| CHEMBL276125 | — | — | 1 | 6.70 |
| CHEMBL169397 | — | — | 1 | 6.70 |
| CHEMBL354224 | — | — | 1 | 6.58 |
| CHEMBL355436 | — | — | 1 | 6.46 |
| CHEMBL170415 | — | — | 1 | 6.36 |
| CHEMBL354830 | — | — | 1 | 6.11 |
| CHEMBL352534 | — | — | 1 | 5.47 |
| CHEMBL352342 | — | — | 1 | 5.34 |
| CHEMBL172746 | — | — | 1 | 5.05 |
| CHEMBL353884 | — | — | 1 | - |
| CHEMBL353668 | — | — | 1 | - |
| CHEMBL171161 | — | — | 1 | - |
| CHEMBL353991 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL171509 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL170519 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL169837 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL170907 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL354898 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL414643 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL168335 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL352308 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL169854 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL167425 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL171413 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL354902 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL276125 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL169397 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL354224 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL355436 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL170415 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL354830 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL352534 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL352342 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL172746 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL353884 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL353668 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL171161 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL353991 | — | IC50 | > | 10000.0 | nM | - |