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Assay Detail

CHEMBL2363230

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
SANGER: Inhibition of human EoL-1-cell cell growth in a cell viability assay.
ChEMBL ↗
120
Total Activities
119
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type EOL1
Confidence 1 — Organism
Curated By Autocuration

Target

EOL1 (CHEMBL614489) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 120 6.33 10.88

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5416410 DASATINIB 4.0 1 10.88
CHEMBL477772 PAZOPANIB 4.0 1 10.54
CHEMBL2041933 AZD-7762 1.0 1 10.44
CHEMBL1289926 AXITINIB 4.0 1 10.29
CHEMBL255863 NILOTINIB 4.0 1 9.84
CHEMBL65 CAMPTOTHECIN -1.0 1 9.57
CHEMBL888 GEMCITABINE 4.0 1 9.21
CHEMBL572881 MOTESANIB 3.0 1 9.03
CHEMBL159 VINBLASTINE 4.0 1 8.90
CHEMBL3545252 DOCETAXEL 4.0 1 8.76
CHEMBL939 GEFITINIB 4.0 1 8.29
CHEMBL443684 NAVITOCLAX 3.0 1 8.17
CHEMBL603469 LESTAURTINIB 3.0 1 8.06
CHEMBL553025 VINORELBINE 4.0 1 8.04
CHEMBL94657 PATUPILONE 3.0 1 7.89
CHEMBL1879463 DACTOLISIB 3.0 1 7.86
CHEMBL449158 BRYOSTATIN 1 2.0 1 7.82
CHEMBL1201182 TEMSIROLIMUS 4.0 1 7.79
CHEMBL325041 BORTEZOMIB 3.0 1 7.74
CHEMBL96926 THAPSIGARGIN — 1 7.62
CHEMBL428647 PACLITAXEL 4.0 1 7.57
CHEMBL53463 DOXORUBICIN 4.0 1 7.56
CHEMBL1256459 TORIN1 — 1 7.52
CHEMBL105442 CI-1040 2.0 1 7.38
CHEMBL514499 GW843682X — 1 7.37
CHEMBL608533 MIDOSTAURIN 4.0 1 7.28
CHEMBL1972860 ELESCLOMOL 3.0 1 7.21
CHEMBL1801204 AZD-8055 1.0 1 7.18
CHEMBL512504 — — 1 7.02
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.94

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5416410 DASATINIB IC50 = 0.01309 nM 10.88
CHEMBL477772 PAZOPANIB IC50 = 0.02889 nM 10.54
CHEMBL2041933 AZD-7762 IC50 = 0.03656 nM 10.44
CHEMBL1289926 AXITINIB IC50 = 0.05132 nM 10.29
CHEMBL255863 NILOTINIB IC50 = 0.1445 nM 9.84
CHEMBL65 CAMPTOTHECIN IC50 = 0.2708 nM 9.57
CHEMBL888 GEMCITABINE IC50 = 0.6162 nM 9.21
CHEMBL572881 MOTESANIB IC50 = 0.9439 nM 9.03
CHEMBL159 VINBLASTINE IC50 = 1.261 nM 8.90
CHEMBL3545252 DOCETAXEL IC50 = 1.727 nM 8.76
CHEMBL939 GEFITINIB IC50 = 5.166 nM 8.29
CHEMBL443684 NAVITOCLAX IC50 = 6.693 nM 8.17
CHEMBL603469 LESTAURTINIB IC50 = 8.685 nM 8.06
CHEMBL553025 VINORELBINE IC50 = 9.086 nM 8.04
CHEMBL94657 PATUPILONE IC50 = 12.9 nM 7.89
CHEMBL1879463 DACTOLISIB IC50 = 13.93 nM 7.86
CHEMBL449158 BRYOSTATIN 1 IC50 = 15.31 nM 7.82
CHEMBL1201182 TEMSIROLIMUS IC50 = 16.1 nM 7.79
CHEMBL325041 BORTEZOMIB IC50 = 18.31 nM 7.74
CHEMBL96926 THAPSIGARGIN IC50 = 24.18 nM 7.62
CHEMBL428647 PACLITAXEL IC50 = 26.88 nM 7.57
CHEMBL53463 DOXORUBICIN IC50 = 27.78 nM 7.56
CHEMBL1256459 TORIN1 IC50 = 29.96 nM 7.52
CHEMBL105442 CI-1040 IC50 = 41.52 nM 7.38
CHEMBL514499 GW843682X IC50 = 42.31 nM 7.37
CHEMBL608533 MIDOSTAURIN IC50 = 52.08 nM 7.28
CHEMBL1972860 ELESCLOMOL IC50 = 62.03 nM 7.21
CHEMBL1801204 AZD-8055 IC50 = 65.69 nM 7.18
CHEMBL512504 — IC50 = 95.58 nM 7.02
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 114.67 nM 6.94
CHEMBL513909 BI-2536 IC50 = 116.72 nM 6.93
CHEMBL1230020 PLX-4720 IC50 = 141.66 nM 6.85
CHEMBL1614701 SELUMETINIB IC50 = 144.76 nM 6.84
CHEMBL507361 MIRDAMETINIB IC50 = 156.62 nM 6.80
CHEMBL105 MITOMYCIN IC50 = 162.39 nM 6.79
CHEMBL379300 A-443654 IC50 = 164.89 nM 6.78
CHEMBL477989 SB590885 IC50 = 180.2 nM 6.74
CHEMBL202721 — IC50 = 186.79 nM 6.73
CHEMBL189963 PALBOCICLIB IC50 = 187.26 nM 6.73
CHEMBL109480 TANESPIMYCIN IC50 = 222.03 nM 6.65
CHEMBL1173655 AFATINIB IC50 = 268.92 nM 6.57
CHEMBL44657 ETOPOSIDE IC50 = 301.72 nM 6.52
CHEMBL189584 PD-173074 IC50 = 329.84 nM 6.48
CHEMBL1190711 — IC50 = 332.75 nM 6.48
CHEMBL572878 TOZASERTIB IC50 = 334.59 nM 6.47
CHEMBL103667 DORAMAPIMOD IC50 = 347.63 nM 6.46
CHEMBL3349342 — IC50 = 399.29 nM 6.40
CHEMBL288441 BOSUTINIB IC50 = 415.76 nM 6.38
CHEMBL413 SIROLIMUS IC50 = 437.98 nM 6.36
CHEMBL98 VORINOSTAT IC50 = 454.25 nM 6.34