Assay Detail
Binding
CHEMBL2186469
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Inhibition of VEGFR1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 1 (CHEMBL1868) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.33 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1289494 | TIVOZANIB | 4.0 | 1 | 9.68 |
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 9.10 |
| CHEMBL572881 | MOTESANIB | 3.0 | 1 | 8.70 |
| CHEMBL2180604 | TAK-593 | 1.0 | 1 | 8.49 |
| CHEMBL491473 | CEDIRANIB | 3.0 | 1 | 8.30 |
| CHEMBL2180605 | — | — | 1 | 8.15 |
| CHEMBL587723 | AEE-788 | 2.0 | 1 | 7.23 |
| CHEMBL101253 | VATALANIB | 3.0 | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1289494 | TIVOZANIB | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL1230609 | FORETINIB | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2180604 | TAK-593 | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL491473 | CEDIRANIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2180605 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL587723 | AEE-788 | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL101253 | VATALANIB | IC50 | = | 110.0 | nM | 6.96 |