Citron Rho-interacting kinase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt O14578. Use UniProt O14578 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O14578 as the stable identity anchor, then attach disease evidence before program review.
Citron Rho-interacting kinase
Review this target as Citron Rho-interacting kinase, mapped to UniProt O14578. Sequence length is 2027 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Citron Rho-interacting kinase as ChEMBL target CHEMBL5579, mapped to UniProt O14578. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Citron Rho-interacting kinase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O14578 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Citron Rho-interacting kinase |
| UniProt Accession | O14578 |
| Component Type | Protein |
| Sequence Length | 2027 aa |
Citron Rho-interacting kinase
Review this target as Citron Rho-interacting kinase, mapped to UniProt O14578. Sequence length is 2027 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5572737 | 9.52 | Kd | 0.3 | Preclinical |
| CHEMBL400402 | 8.52 | Kd | 3.0 | Preclinical |
| CHEMBL5591534 | 8.26 | IC50 | 5.5 | Preclinical |
| CHEMBL5568742 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL5572737 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL5595104 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL379218 | 7.89 | Kd | 13.0 | Preclinical |
| CHEMBL5575901 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL5569359 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL5579704 | 7.8 | IC50 | 16.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 111 | 106 | 6.6 |
| assay format | 25 | 1 | 5.6 |
| cell-based format | 6 | 3 | 7.5 |
| subcellular format | 1 | 19 | 6.0 |