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Evidence Snapshot

Citron Rho-interacting kinase

CHEMBL5579 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:44:14Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5579
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Citron Rho-interacting kinase as ChEMBL target CHEMBL5579, mapped to UniProt O14578. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Citron Rho-interacting kinase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL5579
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O14578
Citron Rho-interacting kinase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Citron Rho-interacting kinase matters

As of 2026-09-13

Citron Rho-interacting kinase is reviewed as Citron Rho-interacting kinase (UniProt O14578); the current evidence base includes 13 approved drugs, 574 compounds, and 143 assays, with lead potency reaching pChEMBL 9.5.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 13 approved drugs, 574 compounds, and 143 assays for this target. The dominant activity type is KD. CHEMBL5572737 is the current potency anchor at pChEMBL 9.5.

Use CHEMBL5572737 as the tractability anchor when discussing potency (pChEMBL 9.5).

Activity source · ChEMBL 36 via Core Engine
13 approved pChEMBL 9.5
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Citron Rho-interacting kinase matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt O14578, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

574
Total Compounds
143
Total Assays
13
Approved Drugs
IC50: 82.0, KI: 5.0, KD: 376.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL5572737
 9.5 Kd —
No preferred name
CHEMBL400402
 8.5 Kd —
No preferred name
CHEMBL5591534
 8.3 IC50 —
No preferred name
CHEMBL5568742
 8.0 IC50 —
No preferred name
CHEMBL5572737
 7.9 IC50 —

Approved Drugs

Structure Compound First Approval
MOMELOTINIB
CHEMBL1078178
 2023
FEDRATINIB
CHEMBL1287853
 2019
ABEMACICLIB
CHEMBL3301610
 2017
ERLOTINIB
CHEMBL553
 2004
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:44:14Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5579