Assay Detail
Binding
CHEMBL4839229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFR1 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 1 (CHEMBL1868) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery, Synthesis, and Evaluation of Highly Selective Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) Inhibitor for the Potential Treatment of Metastatic Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.16 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL572881 | MOTESANIB | 3.0 | 1 | 8.70 |
| CHEMBL491473 | CEDIRANIB | 3.0 | 1 | 8.30 |
| CHEMBL2220486 | LUCITANIB | 2.0 | 1 | 8.15 |
| CHEMBL477772 | PAZOPANIB | 4.0 | 1 | 8.00 |
| CHEMBL1289601 | LENVATINIB | 4.0 | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL572881 | MOTESANIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL491473 | CEDIRANIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2220486 | LUCITANIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1289601 | LENVATINIB | IC50 | = | 22.0 | nM | 7.66 |