Assay Detail
Functional
CHEMBL1018863
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Cytotoxicity against human RPMI8402 cells after 4 days by MTT method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI 8402 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.35 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186397 | — | — | 1 | 9.15 |
| CHEMBL70790 | — | — | 1 | 8.70 |
| CHEMBL184515 | — | — | 1 | 8.52 |
| CHEMBL492517 | — | — | 1 | 8.52 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.40 |
| CHEMBL492927 | — | — | 1 | 7.62 |
| CHEMBL522149 | — | — | 1 | 7.60 |
| CHEMBL494534 | — | — | 1 | 7.52 |
| CHEMBL492516 | — | — | 1 | 7.52 |
| CHEMBL492716 | — | — | 1 | 7.48 |
| CHEMBL494731 | — | — | 1 | 7.48 |
| CHEMBL522190 | — | — | 1 | 7.40 |
| CHEMBL492742 | — | — | 1 | 7.35 |
| CHEMBL492943 | — | — | 1 | 6.75 |
| CHEMBL521992 | — | — | 1 | 6.52 |
| CHEMBL524009 | — | — | 1 | 6.52 |
| CHEMBL522147 | — | — | 1 | 6.42 |
| CHEMBL494536 | — | — | 1 | 6.22 |
| CHEMBL492944 | — | — | 1 | 6.00 |
| CHEMBL494535 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186397 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL70790 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL184515 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL492517 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL492927 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL522149 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL494534 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL492516 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL492716 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL494731 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL522190 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL492742 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL492943 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL521992 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL524009 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL522147 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL494536 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL492944 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL494535 | — | IC50 | = | 4000.0 | nM | 5.40 |