Assay Detail
Functional
CHEMBL1018867
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Cytotoxicity against human KB3-1 cells after 4 days by MTT method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.34 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186397 | — | — | 1 | 8.52 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 8.40 |
| CHEMBL492517 | — | — | 1 | 8.40 |
| CHEMBL184515 | — | — | 1 | 8.30 |
| CHEMBL70790 | — | — | 1 | 8.30 |
| CHEMBL494534 | — | — | 1 | 7.60 |
| CHEMBL492927 | — | — | 1 | 7.60 |
| CHEMBL492716 | — | — | 1 | 7.52 |
| CHEMBL494731 | — | — | 1 | 7.52 |
| CHEMBL522190 | — | — | 1 | 7.51 |
| CHEMBL492943 | — | — | 1 | 7.40 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.40 |
| CHEMBL492516 | — | — | 1 | 7.35 |
| CHEMBL522149 | — | — | 1 | 7.30 |
| CHEMBL492742 | — | — | 1 | 6.80 |
| CHEMBL521992 | — | — | 1 | 6.77 |
| CHEMBL522147 | — | — | 1 | 6.52 |
| CHEMBL524009 | — | — | 1 | 6.50 |
| CHEMBL492944 | — | — | 1 | 6.40 |
| CHEMBL494536 | — | — | 1 | 6.22 |
| CHEMBL494535 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186397 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL492517 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL184515 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL70790 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL494534 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL492927 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL492716 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL494731 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL522190 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL492943 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL492516 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL522149 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL492742 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL521992 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL522147 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL524009 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL492944 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL494536 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL494535 | — | IC50 | = | 1500.0 | nM | 5.82 |