Assay Detail
Binding
CHEMBL1018873
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant phospholipase C gamma2 expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemical assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (CHEMBL4100) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The identification of novel PLC-gamma inhibitors using virtual high throughput screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.57 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509134 | — | — | 1 | 6.00 |
| CHEMBL475789 | — | — | 1 | 6.00 |
| CHEMBL475790 | — | — | 1 | 6.00 |
| CHEMBL455766 | — | — | 1 | 5.70 |
| CHEMBL475623 | — | — | 1 | 5.70 |
| CHEMBL516039 | — | — | 1 | 5.70 |
| CHEMBL473613 | — | — | 1 | 5.52 |
| CHEMBL475627 | — | — | 1 | 5.40 |
| CHEMBL475466 | — | — | 1 | 5.30 |
| CHEMBL473614 | — | — | 1 | 5.02 |
| CHEMBL475390 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509134 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL475789 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL475790 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL455766 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL475623 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL516039 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL473613 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL475627 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL475466 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL473614 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL475390 | — | IC50 | = | 12000.0 | nM | 4.92 |