Compound Detail
CHEMBL475390
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Basic Information
| ChEMBL ID | CHEMBL475390 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RLTNIWJCLHLMDP-XYOKQWHBSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
300.3
MW (Da)
3.00
ALogP
6
HBA
0
HBD
81.8
PSA (Ų)
0.38
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 CHEMBL4100 | IC50 | 4.92 | 4.92 | 12000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | IC50 | = | 12000.0 | nM | 4.92 | Inhibition of recombinant phospholipase C gamma2 expressed in baculovirus infect... | 19303309 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19303309 | 10.1016/j.bmc.2009.02.049 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | 2 |
Data from ChEMBL 36 via Core Engine