Assay Detail
Binding
CHEMBL1018991
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Displacement of [3H]Quisqualate from human mGluR1A receptor expressed in BHK cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BHK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.24 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.24 |
| CHEMBL467234 | — | — | 1 | 4.23 |
| CHEMBL444718 | — | — | 1 | - |
| CHEMBL450025 | — | — | 1 | - |
| CHEMBL448885 | — | — | 1 | - |
| CHEMBL445241 | — | — | 1 | - |
| CHEMBL467235 | — | — | 1 | - |
| CHEMBL33567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL467234 | — | Ki | = | 59000.0 | nM | 4.23 |
| CHEMBL444718 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL450025 | — | Ki | = | 210000.0 | nM | - |
| CHEMBL448885 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL445241 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL467235 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL33567 | — | Ki | > | 1000000.0 | nM | - |