Assay Detail
Binding
CHEMBL1019314
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human serum BChE by Ellman's method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.45 | 5.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.13 |
| CHEMBL513236 | — | — | 1 | 4.79 |
| CHEMBL492098 | — | — | 1 | 4.48 |
| CHEMBL474836 | — | — | 1 | 4.36 |
| CHEMBL490507 | — | — | 1 | 4.22 |
| CHEMBL470907 | — | — | 1 | 4.15 |
| CHEMBL491526 | — | — | 1 | 4.05 |
| CHEMBL471581 | — | — | 1 | - |
| CHEMBL511468 | — | — | 1 | - |
| CHEMBL491346 | — | — | 1 | - |
| CHEMBL523311 | — | — | 1 | - |
| CHEMBL491527 | — | — | 1 | - |
| CHEMBL491528 | — | — | 1 | - |
| CHEMBL491562 | — | — | 1 | - |
| CHEMBL490360 | — | — | 1 | - |
| CHEMBL514966 | — | — | 1 | - |
| CHEMBL474837 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 7420.0 | nM | 5.13 |
| CHEMBL513236 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL492098 | — | IC50 | = | 33200.0 | nM | 4.48 |
| CHEMBL474836 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL490507 | — | IC50 | = | 60700.0 | nM | 4.22 |
| CHEMBL470907 | — | IC50 | = | 71500.0 | nM | 4.15 |
| CHEMBL491526 | — | IC50 | = | 88800.0 | nM | 4.05 |
| CHEMBL471581 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL511468 | — | IC50 | = | 172000.0 | nM | - |
| CHEMBL491346 | — | IC50 | - | — | - | |
| CHEMBL523311 | — | IC50 | - | — | - | |
| CHEMBL491527 | — | IC50 | - | — | - | |
| CHEMBL491528 | — | IC50 | - | — | - | |
| CHEMBL491562 | — | IC50 | - | — | - | |
| CHEMBL490360 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL514966 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL474837 | — | IC50 | > | 100000.0 | nM | - |