Assay Detail
Functional
CHEMBL1019476
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Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dark up to 1 hr
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The identification of orally bioavailable thrombopoietin agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.04 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429295 | — | — | 1 | 8.15 |
| CHEMBL455654 | — | — | 1 | 8.00 |
| CHEMBL462874 | — | — | 1 | 7.55 |
| CHEMBL523975 | — | — | 1 | 7.48 |
| CHEMBL516993 | — | — | 1 | 7.47 |
| CHEMBL461174 | — | — | 1 | 7.37 |
| CHEMBL459474 | — | — | 1 | 7.30 |
| CHEMBL459687 | — | — | 1 | 7.25 |
| CHEMBL524116 | — | — | 1 | 7.24 |
| CHEMBL490096 | — | — | 1 | 6.89 |
| CHEMBL461974 | — | — | 1 | 6.87 |
| CHEMBL461975 | — | — | 1 | 6.86 |
| CHEMBL462144 | — | — | 1 | 6.60 |
| CHEMBL489309 | — | — | 1 | 6.53 |
| CHEMBL523097 | — | — | 1 | 6.37 |
| CHEMBL518057 | — | — | 1 | 6.31 |
| CHEMBL465957 | — | — | 1 | 5.48 |
| CHEMBL455445 | — | — | 1 | - |
| CHEMBL463814 | — | — | 1 | - |
| CHEMBL461100 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429295 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL455654 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL462874 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL523975 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL516993 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL461174 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL459474 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL459687 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL524116 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL490096 | — | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL461974 | — | EC50 | = | 134.0 | nM | 6.87 |
| CHEMBL461975 | — | EC50 | = | 138.0 | nM | 6.86 |
| CHEMBL462144 | — | EC50 | = | 253.0 | nM | 6.60 |
| CHEMBL489309 | — | EC50 | = | 294.0 | nM | 6.53 |
| CHEMBL523097 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL518057 | — | EC50 | = | 485.0 | nM | 6.31 |
| CHEMBL465957 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL455445 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL463814 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL461100 | — | EC50 | > | 1000.0 | nM | - |