Compound Detail
CHEMBL524116
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
C[C@@H](Nc1ncc(C(=O)Nc2nc(-c3cccc(C(F)(F)F)c3F)cs2)cc1Cl)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL524116 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CKUZRSZSEGTVJO-MRVPVSSYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
488.9
MW (Da)
5.15
ALogP
6
HBA
3
HBD
104.2
PSA (Ų)
0.41
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thrombopoietin receptor CHEMBL1864 | EC50 | 7.24 | 7.24 | 57.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thrombopoietin receptor | EC50 | = | 57.0 | nM | 7.24 | Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cell... | 19186055 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19186055 | 10.1016/j.bmcl.2009.01.032 | No relevant target | 2 |
| 19186055 | 10.1016/j.bmcl.2009.01.032 | Thrombopoietin receptor | 1 |
Data from ChEMBL 36 via Core Engine