Assay Detail
Binding
CHEMBL1019480
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Displacement of [3H]dopamine from human recombinant DAT expressed in HEK293 cells by scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dual inhibitors of phosphodiesterase-4 and serotonin reuptake.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.21 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.52 |
| CHEMBL505431 | — | — | 1 | 5.45 |
| CHEMBL451500 | — | — | 1 | 5.27 |
| CHEMBL450907 | — | — | 1 | 4.77 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 4.71 |
| CHEMBL464422 | — | — | 1 | 4.55 |
| CHEMBL313041 | — | — | 1 | - |
| CHEMBL463431 | — | — | 1 | - |
| CHEMBL473966 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370805 | COCAINE | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL505431 | — | IC50 | = | 3556.0 | nM | 5.45 |
| CHEMBL451500 | — | IC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL450907 | — | IC50 | = | 16987.0 | nM | 4.77 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL464422 | — | IC50 | = | 27850.0 | nM | 4.55 |
| CHEMBL313041 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL463431 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL473966 | — | IC50 | > | 100000.0 | nM | - |